pI: 7.7924 |
Length (AA): 337 |
MW (Da): 37369 |
Paralog Number:
7
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 9
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129243)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G28315 | nucleotide/sugar transporter-like protein |
Arabidopsis thaliana | AT1G06890 | nucleotide/sugar transporter family protein |
Arabidopsis thaliana | AT2G30460 | Nucleotide/sugar transporter family protein |
Cryptosporidium parvum | cgd4_3110 | 10 transmembrane domain protein, possible translocator |
Homo sapiens | 55508 | solute carrier family 35, member E3 |
Leishmania braziliensis | LbrM.19.1770 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_191540.1 | Triose-phosphate Transporter family, putative |
Leishmania donovani | LdBPK_302680.1 | Triose-phosphate Transporter family, putative |
Leishmania infantum | LinJ.30.2680 | hypothetical protein, conserved |
Leishmania infantum | LinJ.19.1540 | hypothetical protein, conserved |
Leishmania major | LmjF.19.1490 | hypothetical protein, conserved |
Leishmania major | LmjF.30.2680 | hypothetical protein, conserved |
Leishmania major | LmjF.19.1510 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.19.1490 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.29.2680 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000060181 | solute carrier family 35, member E3 |
Oryza sativa | 4325183 | Os01g0167500 |
Oryza sativa | 4348916 | Os10g0479700 |
Oryza sativa | 4337925 | Os05g0168700 |
Oryza sativa | 4330044 | Os02g0628200 |
Trypanosoma brucei gambiense | Tbg972.6.3740 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.6.3960 | Nucleotide sugar transporter 4 |
Trypanosoma congolense | TcIL3000_6_3380 | Triose-phosphate Transporter family, putative |
Trypanosoma congolense | TcIL3000_0_02330 | Triose-phosphate Transporter family, putative |
Trypanosoma cruzi | TcCLB.511353.30 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511517.150 | Triose-phosphate Transporter family, putative |
Trypanosoma cruzi | TcCLB.511301.50 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511737.70 | Triose-phosphate Transporter family, putative |
Trichomonas vaginalis | TVAG_147630 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_291580 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_476380 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_461060 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_140070 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_153420 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_031760 | protein C22F8.04 in chromosome I, putative |
Trichomonas vaginalis | TVAG_108280 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.3960 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.3960 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.3960 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.6.3960 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.