Detailed view for TVAG_258290

Basic information

TDR Targets ID: 841796
Trichomonas vaginalis, AGC family protein kinase
Source Database / ID: 

pI: 6.8208 | Length (AA): 471 | MW (Da): 53973 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131896)

Species Accession Gene Product
Babesia bovis BBOV_III003130   protein kinase domain containing protein
Candida albicans CaO19.8058   similar to S. cerevisiae IKS1 (YJL057C) kinase suppressor of Ira1
Candida albicans CaO19.428   similar to S. cerevisiae IKS1 (YJL057C) kinase suppressor of Ira1
Cryptosporidium hominis Chro.70346   hypothetical protein
Cryptosporidium parvum cgd7_3080   hypothetical protein
Dictyostelium discoideum DDB_G0283109   IKS family protein kinase
Leishmania braziliensis LbrM.25.2570   protein kinase, putative
Leishmania donovani LdBPK_251580.1   protein kinase, putative
Leishmania infantum LinJ.25.1580   protein kinase, putative
Leishmania major LmjF.25.1520   protein kinase, putative
Leishmania mexicana LmxM.25.1520   protein kinase, putative
Neospora caninum NCLIV_034010   Wee kinase, putative
Saccharomyces cerevisiae YJL057C   Iks1p
Trypanosoma brucei gambiense Tbg972.3.1350   protein kinase, putative
Trypanosoma brucei Tb927.3.1570   Lapatinib-binding protein kinase 3
Trypanosoma congolense TcIL3000_0_56770   protein kinase, putative
Trypanosoma congolense TcIL3000_3_660   protein kinase, putative
Trypanosoma cruzi TcCLB.510089.80   protein kinase, putative
Trypanosoma cruzi TcCLB.510421.90   protein kinase, putative
Toxoplasma gondii TGME49_273690   Wee kinase
Theileria parva TP04_0139   serine/threonine protein kinase, putative
Trichomonas vaginalis TVAG_258290   AGC family protein kinase

Essentiality

TVAG_258290 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.1570 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.1570 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.1570 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.3.1570 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_273690 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 24.0% 196 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 20.3% 305 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 25.5% 235 aa Compounds References
Patiria pectinifera Cdc2 300 aa 23.4% 265 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 20.3% 305 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.8% 256 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 20.2% 292 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0032 0.5 0.5
0.0039 0.5 0.5
0.0037 1 0.5
0.0007 0.5 0.5
0.0012 0.5 0.5
0.0033 1 1
0.0016 0.5 0.5
0.0064 0.3377 0.5
0.0063 0.7244 0
0.0059 1 1
0.0022 0.5 0.5
0.0093 0.8828 0.5
0.0032 0.5 0.5
0.0088 0.4477 1
0.0081 1 0.5
0.0056 1 0.5
0.0026 0.5 0.5
0.0039 0.5 0.5
0.0036 0.5 0.5
0.0061 0.6883 0.5304
0.0027 1 0.5
0.0016 0.5 0.5
0.0067 0.5 0.5
0.0066 0.3101 0.5
0.0062 0.6935 0.5
0.0059 1 1
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0039 0.9485 0.5
0.0098 0.3242 0.2373
0.0008 0.5 0.5
0.0029 0.5 0.5
0.0092 1 0.5
0.0011 1 0.5
0.0007 0.5 0.5
0.0033 0.5 0.5
0.0063 1 1
0.0004 0.5 0.5
0.0091 1 0.5
0.0081 0.5 0.5
0.0069 0.3067 0.5
0.0059 1 1
0.0042 0.5 0.5
0.0018 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_258290 (Trichomonas vaginalis), AGC family protein kinase
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