pI: 8.3573 |
Length (AA): 448 |
MW (Da): 48744 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127447)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G04170 | translation initiation factor eIF-2 gamma subunit |
Arabidopsis thaliana | AT2G18720 | translation elongation factor EF1A/initiation factor IF2gamma family protein |
Arabidopsis thaliana | AT4G18330 | putative translation elongation factor 2EF1A / eIF-2-gamma |
Babesia bovis | BBOV_IV004190 | translation initiation factor 2 gamma subunit, putative |
Brugia malayi | Bm1_48910 | eIF2 gamma |
Candida albicans | CaO19.11699 | similar to S. cerevisiae GCD11 (YER025W) translation initiation factor eIF2 gamma subunit |
Candida albicans | CaO19.4223 | similar to S. cerevisiae GCD11 (YER025W) translation initiation factor eIF2 gamma subunit |
Caenorhabditis elegans | CELE_Y39G10AR.8 | Protein Y39G10AR.8 |
Cryptosporidium hominis | Chro.30199 | translation initiation factor eIF-2 |
Cryptosporidium parvum | cgd3_1650 | eIF2G GTpase. eukaryotic translation initiation factor 2 gamma subunit (ZnR+GTpase) |
Dictyostelium discoideum | DDB_G0278967 | translation initiation factor 2 gamma |
Drosophila melanogaster | Dmel_CG43665 | Eukaryotic initiation factor 2gamma |
Echinococcus granulosus | EgrG_000490900 | eukaryotic translation initiation |
Entamoeba histolytica | EHI_132880 | eukaryotic translation initiation factor 2 gamma subunit, putative |
Echinococcus multilocularis | EmuJ_000490900 | eukaryotic translation initiation |
Giardia lamblia | GL50803_2970 | Translation initiation factor 2 gamma subunit |
Homo sapiens | 1968 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa |
Leishmania braziliensis | LbrM.09.1130 | eukaryotic translation initiation factor 2 subunit, putative |
Leishmania infantum | LinJ.09.1130 | eukaryotic translation initiation factor 2 subunit, putative |
Leishmania major | LmjF.09.1070 | eukaryotic translation initiation factor 2 subunit, putative |
Leishmania mexicana | LmxM.09.1070 | eukaryotic translation initiation factor 2 subunit, putative |
Loa Loa (eye worm) | LOAG_03629 | hypothetical protein |
Mus musculus | 102642679 | eukaryotic translation initiation factor 2 subunit 3-like |
Mus musculus | ENSMUSG00000035150 | eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked |
Mus musculus | ENSMUSG00000069049 | eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked |
Neospora caninum | NCLIV_050300 | GH18750, related |
Oryza sativa | 4352748 | Os12g0607100 |
Oryza sativa | 4351657 | Os12g0176800 |
Onchocerca volvulus | OVOC904 | Eukaryotic translation initiation factor 2 subunit 3 homolog |
Plasmodium berghei | PBANKA_1031900 | eukaryotic translation initiation factor 2 subunit gamma, putative |
Plasmodium falciparum | PF3D7_1410600 | eukaryotic translation initiation factor 2 subunit gamma, putative |
Plasmodium knowlesi | PKNH_1347700 | eukaryotic translation initiation factor 2 subunit gamma, putative |
Plasmodium vivax | PVX_085920 | eukaryotic translation initiation factor 2 gamma subunit, putative |
Plasmodium yoelii | PY04028 | translation initiation factor eIF-2 |
Saccharomyces cerevisiae | YER025W | translation initiation factor eIF2 subunit gamma |
Schistosoma japonicum | Sjp_0219200 | ko:K03242 translation initiation factor eIF-2 gamma subunit, putative |
Schistosoma mansoni | Smp_095150 | eukaryotic translation initiation factor 2 gamma subunit (eif-2-gamma) |
Schmidtea mediterranea | mk4.000013.24 | Eukaryotic translation initiation factor 2 subunit 3 |
Schmidtea mediterranea | mk4.001673.00 | Eukaryotic translation initiation factor 2 subunit 3 |
Trypanosoma brucei gambiense | Tbg972.11.14790 | eukaryotic translation initiation factor 2 gamma, putative |
Trypanosoma brucei | Tb927.11.13250 | eukaryotic translation initiation factor 2 gamma, putative |
Trypanosoma congolense | TcIL3000.11.13610 | eukaryotic translation initiation factor 2 gamma, putative |
Trypanosoma cruzi | TcCLB.510359.310 | eukaryotic translation initiation factor 2 subunit, putative |
Trypanosoma cruzi | TcCLB.503819.30 | eukaryotic translation initiation factor 2 subunit, putative |
Toxoplasma gondii | TGME49_235970 | eukaryotic initiation factor-2 gamma, putative |
Theileria parva | TP01_0335 | eukaryotic translation initiation factor 2 gamma subunit, putative |
Trichomonas vaginalis | TVAG_423490 | eukaryotic translation initiation factor 2 gamma subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.4830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.4830 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.4830 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.4830 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y39G10AR.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y39G10AR.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y39G10AR.8 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y39G10AR.8 | Caenorhabditis elegans | sterile | wormbase |
YER025W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_235970 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.