Detailed view for TVAG_476340

Basic information

TDR Targets ID: 845088
Trichomonas vaginalis, hypothetical protein
Source Database / ID: 

pI: 4.7976 | Length (AA): 668 | MW (Da): 76808 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08318   COG4 transport protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129076)

Species Accession Gene Product
Arabidopsis thaliana AT4G01400   hypothetical protein
Brugia malayi Bm1_01690   Conserved oligomeric Golgi complex component 4, putative
Candida albicans CaO19.6880   similar to S. cerevisiae COG4 (YPR105C) intra-Golgi transport complex subunit
Candida albicans CaO19.14169   similar to S. cerevisiae COG4 (YPR105C) intra-Golgi transport complex component
Caenorhabditis elegans CELE_Y51H7C.6   Protein COGC-4, isoform A
Cryptosporidium parvum cgd7_3750   oligomeric golgi complex protein 4
Dictyostelium discoideum DDB_G0267960   oligomeric Golgi complex component
Drosophila melanogaster Dmel_CG7456   CG7456 gene product from transcript CG7456-RA
Echinococcus granulosus EgrG_000481000   oligomeric Golgi complex subunit
Echinococcus multilocularis EmuJ_000481000   oligomeric Golgi complex subunit
Homo sapiens ENSG00000103051   component of oligomeric golgi complex 4
Loa Loa (eye worm) LOAG_00872   hypothetical protein
Mus musculus ENSMUSG00000031753   component of oligomeric golgi complex 4
Oryza sativa 9267023   Os02g0456000
Saccharomyces cerevisiae YPR105C   Cog4p
Schistosoma japonicum Sjp_0010360   Conserved oligomeric Golgi complex component 4, putative
Schistosoma japonicum Sjp_0010340   Conserved oligomeric Golgi complex component 4, putative
Schistosoma mansoni Smp_192100   hypothetical protein
Schistosoma mansoni Smp_118480   hypothetical protein
Schistosoma mansoni Smp_166460   oligomeric golgi complex component
Schistosoma mansoni Smp_180640   hypothetical protein
Schistosoma mansoni Smp_121530   hypothetical protein
Schistosoma mansoni Smp_080070   hypothetical protein
Schmidtea mediterranea mk4.001556.10  
Schmidtea mediterranea mk4.001556.07   Conserved oligomeric Golgi complex subunit 4
Schmidtea mediterranea mk4.001556.08   Conserved oligomeric Golgi complex subunit 4
Trichomonas vaginalis TVAG_476340   hypothetical protein

Essentiality

TVAG_476340 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y51H7C.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y51H7C.6 Caenorhabditis elegans larval arrest wormbase
CELE_Y51H7C.6 Caenorhabditis elegans larval lethal wormbase
CELE_Y51H7C.6 Caenorhabditis elegans slow growth wormbase
CELE_Y51H7C.6 Caenorhabditis elegans sterile wormbase
YPR105C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_476340 (Trichomonas vaginalis), hypothetical protein
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