pI: 6.7323 |
Length (AA): 408 |
MW (Da): 46703 |
Paralog Number:
179
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_126770)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_15000 | Adenylate and Guanylate cyclase catalytic domain containing protein |
Dictyostelium discoideum | DDB_G0274569 | adenylate cyclase |
Loa Loa (eye worm) | LOAG_13680 | hypothetical protein |
Loa Loa (eye worm) | LOAG_03815 | hypothetical protein |
Mycobacterium tuberculosis | Rv1625c | Membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase) (adenylate cyclase) |
Mycobacterium ulcerans | MUL_2284 | hypothetical protein |
Trichomonas vaginalis | TVAG_327930 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_298220 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_021840 | adenylate cyclase, type VII, putative |
Trichomonas vaginalis | TVAG_162120 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_298410 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_273280 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_451980 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_124800 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_358630 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_391080 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_116480 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_298390 | soluble guanylate cyclase gcy, putative |
Trichomonas vaginalis | TVAG_322510 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_052910 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_411720 | adenylate cyclase type VI, putative |
Trichomonas vaginalis | TVAG_024960 | adenylate cyclase type IX, putative |
Trichomonas vaginalis | TVAG_124790 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_219760 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_411240 | adenylate cyclase, type VII, putative |
Trichomonas vaginalis | TVAG_360130 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_336830 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_162110 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_155240 | adenylate cyclase type IX, putative |
Trichomonas vaginalis | TVAG_431840 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_291050 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_127600 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_383510 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_102500 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_270460 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_101980 | soluble guanylate cyclase gcy, putative |
Trichomonas vaginalis | TVAG_360120 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_363510 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_406770 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_360140 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_098530 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_357240 | guanylate cyclase beta 2 subunit, putative |
Trichomonas vaginalis | TVAG_098520 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_228010 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_353640 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_036810 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_604010 | guanylate cyclase beta 2 subunit, putative |
Trichomonas vaginalis | TVAG_017920 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_038510 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_344240 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_353630 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_360150 | soluble guanylate cyclase gcy, putative |
Trichomonas vaginalis | TVAG_451970 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_399750 | adenylate cyclase type VI, putative |
Trichomonas vaginalis | TVAG_383490 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_213300 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_373640 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_420130 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_194370 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_281080 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_459500 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_373670 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_365230 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_411250 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_489980 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_052920 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_219670 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_247080 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_373630 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_298210 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_415250 | adenylate cyclase type IX, putative |
Trichomonas vaginalis | TVAG_219680 | guanylate cyclase beta 1 subunit, putative |
Trichomonas vaginalis | TVAG_082230 | retinal guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_095290 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_255630 | adenylate cyclase type III, putative |
Trichomonas vaginalis | TVAG_453250 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_062940 | atrial natriuretic peptide receptor, putative |
Trichomonas vaginalis | TVAG_119490 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_087300 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_072540 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_406780 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_116470 | intestinal guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_057590 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_431830 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_158250 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_151410 | adenylyl cyclase type V, putative |
Trichomonas vaginalis | TVAG_017910 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_008510 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_336810 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_406790 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_287980 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_TEG_DS113747_3_1 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_008520 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_228390 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_138040 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_391070 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_451130 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_218150 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_194440 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_147310 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_057580 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_303820 | atrial natriuretic peptide receptor, putative |
Trichomonas vaginalis | TVAG_255620 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_021130 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_318180 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_284780 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_145640 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_505880 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_025690 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_158530 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_034630 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_136140 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_457380 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_459490 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_124920 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_299950 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_235080 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_456550 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_101890 | adenylate cyclase type IX, putative |
Trichomonas vaginalis | TVAG_145650 | adenylate cyclase type III, putative |
Trichomonas vaginalis | TVAG_051550 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_446260 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_457220 | adenylate cyclase type, putative |
Trichomonas vaginalis | TVAG_344250 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_128850 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_490080 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_186390 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_072530 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_168430 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_138030 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_425200 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_052960 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_124910 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_158550 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_303810 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_167510 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_273290 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_353620 | retinal guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_392570 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_052940 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_358620 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_350120 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_489970 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_350270 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_425640 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_127610 | adenylate cyclase type, putative |
Trichomonas vaginalis | TVAG_052950 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_095300 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_373660 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_365240 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_147320 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_467090 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_082220 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_162100 | soluble guanylate cyclase gcy, putative |
Trichomonas vaginalis | TVAG_021120 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_052930 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_298400 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_406800 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_357550 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_391060 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_101990 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_318170 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_383500 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_138020 | soluble guanylate cyclase gcy, putative |
Trichomonas vaginalis | TVAG_318160 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_336820 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_013980 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_284770 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_124900 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_092700 | adenylyl cyclase type V, putative |
Trichomonas vaginalis | TVAG_158540 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_436960 | adenylate cyclase type, putative |
Trichomonas vaginalis | TVAG_431850 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_373650 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_315830 | adenylate and guanylate cyclases, putative |
Trichomonas vaginalis | TVAG_581670 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_564290 | adenylate cyclase type III, putative |
Trichomonas vaginalis | TVAG_145630 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_298230 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_052900 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_307730 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_290500 | guanylate cyclase, putative |
Trichomonas vaginalis | TVAG_098510 | soluble guanylate cyclase gcy, putative |
Trichomonas vaginalis | TVAG_302910 | adenylate cyclase, putative |
Trichomonas vaginalis | TVAG_415270 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_406810 | conserved hypothetical protein |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.