Detailed view for TVAG_116360

Basic information

TDR Targets ID: 848585
Trichomonas vaginalis, Rab17, putative
Source Database / ID: 

pI: 5.1005 | Length (AA): 199 | MW (Da): 22587 | Paralog Number: 15

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  
GO:0003924   GTPase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132710)

Species Accession Gene Product
Candida albicans CaO19.8060   one of two genes similar to S. cerevisiae VPT52 (YKR014C) rab5-like GTPase involved in vacuolar protein sorting and endocytosis
Candida albicans CaO19.430   one of two genes similar to S. cerevisiae VPT52 (YKR014C) rab5-like GTPase involved in vacuolar protein sorting and endocytosis
Dictyostelium discoideum DDB_G0277441   Rab GTPase
Drosophila melanogaster Dmel_CG3870   CG3870 gene product from transcript CG3870-RA
Neospora caninum NCLIV_060890   Ras family domain-containing protein, putative
Saccharomyces cerevisiae YNL093W   Rab family GTPase YPT53
Schmidtea mediterranea mk4.002539.03  
Toxoplasma gondii TGME49_219720   Ras-related protein Rab-5C, putative
Trichomonas vaginalis TVAG_531820   Rab17, putative
Trichomonas vaginalis TVAG_019470   RAB, putative
Trichomonas vaginalis TVAG_024790   septum-promoting GTP-binding protein, putative
Trichomonas vaginalis TVAG_179640   Rab21, putative
Trichomonas vaginalis TVAG_453170   GTP-binding protein ypt11, putative
Trichomonas vaginalis TVAG_020610   RAB-18, putative
Trichomonas vaginalis TVAG_349870   Rabx15 protein, putative
Trichomonas vaginalis TVAG_328110   RAB-18, putative
Trichomonas vaginalis TVAG_474500   Rabx26 protein, putative
Trichomonas vaginalis TVAG_090060   GTP-binding protein Rab2, putative
Trichomonas vaginalis TVAG_074410   Rabx41 protein, putative
Trichomonas vaginalis TVAG_211200   Rabx21 protein, putative
Trichomonas vaginalis TVAG_257310   Rab21, putative
Trichomonas vaginalis TVAG_116360   Rab17, putative
Trichomonas vaginalis TVAG_317250   Rabx2a protein, putative
Trichomonas vaginalis TVAG_391920   Rab7g protein, putative

Essentiality

TVAG_116360 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_219720 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_116360 (Trichomonas vaginalis), Rab17, putative
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