pI: 6.1924 |
Length (AA): 470 |
MW (Da): 54603 |
Paralog Number:
7
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127556)
Species | Accession | Gene Product |
---|---|---|
Candida albicans | CaO19.7016 | vacuolar polyphosphatase |
Candida albicans | CaO19_7016 | hypothetical protein |
Caenorhabditis elegans | CELE_ZK856.5 | Protein ZK856.5 |
Caenorhabditis elegans | CELE_ZK856.18 | Protein ZK856.18 |
Dictyostelium discoideum | DDB_G0268330 | hypothetical protein |
Dictyostelium discoideum | DDB_G0282265 | metallophosphoesterase domain-containing protein |
Drosophila melanogaster | Dmel_CG32052 | CG32052 gene product from transcript CG32052-RC |
Echinococcus granulosus | EgrG_001109500 | acid sphingomyelinase phosphodiesterase 3b |
Entamoeba histolytica | EHI_172510 | acid sphingomyelinase-like phosphodiesterase 3a precursor, putative |
Entamoeba histolytica | EHI_125660 | acid sphingomyelinase-like phosphodiesterase, putative |
Entamoeba histolytica | EHI_100080 | acid sphingomyelinase-like phosphodiesterase, putative |
Echinococcus multilocularis | EmuJ_001109500 | acid sphingomyelinase phosphodiesterase 3b |
Giardia lamblia | GL50803_16737 | Acid sphingomyelinase-like phosphodiesterase 3b precursor |
Giardia lamblia | GL50803_8360 | Acid sphingomyelinase-like phosphodiesterase 3b precursor |
Homo sapiens | ENSG00000172594 | sphingomyelin phosphodiesterase, acid-like 3A |
Homo sapiens | ENSG00000130768 | sphingomyelin phosphodiesterase, acid-like 3B |
Leishmania braziliensis | LbrM.20.3210 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_343410.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.34.3410 | hypothetical protein, conserved |
Leishmania infantum | LinJ.35.0640 | beta-fructofuranosidase-like protein |
Leishmania major | LmjF.34.3630 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.33.3630 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000019872 | sphingomyelin phosphodiesterase, acid-like 3A |
Mus musculus | ENSMUSG00000028885 | sphingomyelin phosphodiesterase, acid-like 3B |
Saccharomyces cerevisiae | YDR452W | Ppn1p |
Schistosoma japonicum | Sjp_0004960 | ko:K01128 SMPDL3B, LOC769013; sphingomyelin phosphodiesterase, acid-like 3B [EC:3.1.4.-], putative |
Schistosoma mansoni | Smp_133330 | hypothetical protein |
Schmidtea mediterranea | mk4.004549.04 | |
Schmidtea mediterranea | mk4.003734.01 | |
Schmidtea mediterranea | mk4.006060.00 | |
Schmidtea mediterranea | mk4.011233.00 | |
Schmidtea mediterranea | mk4.002408.04 | |
Schmidtea mediterranea | mk4.003734.02 | |
Schmidtea mediterranea | mk4.043629.00 | |
Schmidtea mediterranea | mk4.007239.04 | |
Schmidtea mediterranea | mk4.000520.08 | |
Trypanosoma brucei gambiense | Tbg972.4.940 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.4.1110 | hypothetical protein, conserved |
Trypanosoma congolense | TcIL3000_0_06660 | Calcineurin-like phosphoesterase, putative |
Trypanosoma cruzi | TcCLB.507251.10 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_576590 | sphingomyelin phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_342080 | sphingomyelin phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_062580 | sphingomyelin phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_271580 | sphingomyelin phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_289530 | sphingomyelin phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_222460 | sphingomyelin phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_352120 | sphingomyelin phosphodiesterase, putative |
Trichomonas vaginalis | TVAG_020780 | sphingomyelin phosphodiesterase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.1110 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.1110 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.1110 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.1110 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.