Detailed view for TVAG_473930

Basic information

TDR Targets ID: 855717
Trichomonas vaginalis, asparagine synthetase, putative
Source Database / ID: 

pI: 6.7138 | Length (AA): 410 | MW (Da): 45564 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00733   Asparagine synthase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004066   asparagine synthase (glutamine-hydrolyzing) activity  
GO:0006529   asparagine biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128527)

Species Accession Gene Product
Arabidopsis thaliana AT2G03667   asparagine synthase
Babesia bovis BBOV_IV006020   asparagine synthase, putative
Brugia malayi Bm1_38315   Asparagine synthase family protein
Candida albicans CaO19.11109   similar to S. cerevisiae YML096W
Candida albicans CaO19.3626   similar to S. cerevisiae YML096W
Caenorhabditis elegans CELE_M18.3   Protein M18.3
Dictyostelium discoideum DDB_G0278193   hypothetical protein
Drosophila melanogaster Dmel_CG17486   CG17486 gene product from transcript CG17486-RB
Echinococcus granulosus EgrG_000668900   asparagine synthetase domain containing protein
Entamoeba histolytica EHI_125770   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000668900   asparagine synthetase domain containing protein
Giardia lamblia GL50803_3372   Asparagine synthase, putative
Homo sapiens ENSG00000138381   asparagine synthetase domain containing 1
Leishmania braziliensis LbrM.29.1580   hypothetical protein, conserved
Leishmania donovani LdBPK_291590.1   asparagine synthase, putative
Leishmania infantum LinJ.29.1590   hypothetical protein, conserved
Leishmania major LmjF.29.1490   hypothetical protein, conserved
Leishmania mexicana LmxM.08_29.1490   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_10277   hypothetical protein
Loa Loa (eye worm) LOAG_12443   asparagine synthase
Mus musculus ENSMUSG00000026095   asparagine synthetase domain containing 1
Oryza sativa 4352605   Os12g0574900
Onchocerca volvulus OVOC4268   Alternative protein ASNSD1 homolog
Saccharomyces cerevisiae YML096W   putative asparagine synthase
Schistosoma japonicum Sjp_0311240   ko:K01953 asparagine synthase (glutamine-hydrolysing) [EC6.3.5.4], putative
Schistosoma mansoni Smp_133560   asparagine synthetase
Schmidtea mediterranea mk4.002665.01   Alternative protein ASNSD1
Trypanosoma brucei gambiense Tbg972.3.4470   hypothetical protein, conserved
Trypanosoma brucei Tb927.3.4060   asparagine synthetase domain-containing protein 1
Trypanosoma congolense TcIL3000_3_2700   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510001.40   asparagine synthase, putative
Trypanosoma cruzi TcCLB.507529.40   asparagine synthase, putative
Theileria parva TP01_0405   hypothetical protein
Trichomonas vaginalis TVAG_473930   asparagine synthetase, putative

Essentiality

TVAG_473930 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.4060 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.4060 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.4060 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.3.4060 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_473930 (Trichomonas vaginalis), asparagine synthetase, putative
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