Detailed view for TVAG_127920

Basic information

TDR Targets ID: 856618
Trichomonas vaginalis, mixed-lineage leukemia protein, mll, putative
Source Database / ID: 

pI: 9.3715 | Length (AA): 351 | MW (Da): 40268 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00856   SET domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127895)

Species Accession Gene Product
Arabidopsis thaliana AT5G42400   histone methyltransferase SDG25
Babesia bovis BBOV_III006000   SET domain containing protein
Brugia malayi Bm1_45235   SET domain containing protein
Candida albicans CaO19.6009   potential histone lysine methyltransferase, similar to S. cerevisiae SET1 (YHR119W) subunit of the COMPASS histone methyltransfe
Candida albicans CaO19.13430   potential histone lysine methyltransferase, similar to S. cerevisiae SET1 (YHR119W) subunit of the COMPASS histone methyltransfe
Caenorhabditis elegans CELE_C26E6.9   Protein SET-2, isoform B
Cryptosporidium hominis Chro.80318   SET-domain protein
Cryptosporidium parvum cgd8_2730   multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a
Dictyostelium discoideum DDB_G0289257   SET domain-containing protein
Drosophila melanogaster Dmel_CG40351   CG40351 gene product from transcript CG40351-RF
Giardia lamblia GL50803_13838   Hypothetical protein
Homo sapiens ENSG00000139718   SET domain containing 1B
Homo sapiens ENSG00000099381   SET domain containing 1A
Loa Loa (eye worm) LOAG_01475   hypothetical protein
Loa Loa (eye worm) LOAG_11302   histone methyltransferase
Mus musculus ENSMUSG00000042308   SET domain containing 1A
Mus musculus ENSMUSG00000038384   SET domain containing 1B
Oryza sativa 4352779   Os12g0613200
Plasmodium berghei PBANKA_1128500   SET domain protein, putative
Plasmodium falciparum PF3D7_0629700   SET domain protein, putative
Plasmodium knowlesi PKNH_1119800   SET domain protein, putative
Plasmodium vivax PVX_114585   SET domain containing protein
Plasmodium yoelii PY00684   Bromodomain, putative
Plasmodium yoelii PY02230   similar to KIAA0304 gene product-related
Saccharomyces cerevisiae YHR119W   Set1p
Schmidtea mediterranea mk4.001072.06   Probable histone-lysine N-methyltransferase set-2
Theileria parva TP04_0805   SET-domain protein, putative
Theileria parva TP04_0804   hypothetical protein, conserved
Trichomonas vaginalis TVAG_127920   mixed-lineage leukemia protein, mll, putative
Trichomonas vaginalis TVAG_185780   mixed-lineage leukemia protein, mll, putative
Trichomonas vaginalis TVAG_440830   PHD finger protein, putative
Trichomonas vaginalis TVAG_162900   mixed-lineage leukemia protein, mll, putative

Essentiality

TVAG_127920 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C26E6.9 Caenorhabditis elegans sterile wormbase
PBANKA_1128500 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_127920 (Trichomonas vaginalis), mixed-lineage leukemia protein, mll, putative
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