pI: 10.6133 |
Length (AA): 526 |
MW (Da): 54186 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128991)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_29495 | WH1 domain containing protein |
Candida albicans | CaO19.6598 | similar to S. cerevisiae LAS17 (YOR181W) actin assembly factor |
Caenorhabditis elegans | CELE_C07G1.4 | Protein WSP-1, isoform B |
Dictyostelium discoideum | DDB_G0281723 | WH2 domain-containing protein |
Dictyostelium discoideum | DDB_G0272811 | WASP-related protein |
Dictyostelium discoideum | DDB_G0293834 | Wiscott-Aldrich syndrome protein |
Drosophila melanogaster | Dmel_CG1520 | CG1520 gene product from transcript CG1520-RA |
Echinococcus granulosus | EgrG_001173500 | neural Wiskott Aldrich syndrome protein |
Echinococcus multilocularis | EmuJ_000845000 | wiskott Aldrich syndrome protein |
Echinococcus multilocularis | EmuJ_001173500 | neural Wiskott Aldrich syndrome protein |
Homo sapiens | ENSG00000106299 | Wiskott-Aldrich syndrome-like |
Homo sapiens | ENSG00000015285 | Wiskott-Aldrich syndrome |
Loa Loa (eye worm) | LOAG_04947 | hypothetical protein |
Mus musculus | ENSMUSG00000031165 | Wiskott-Aldrich syndrome homolog (human) |
Mus musculus | ENSMUSG00000029684 | Wiskott-Aldrich syndrome-like (human) |
Saccharomyces cerevisiae | YOR181W | Las17p |
Schistosoma japonicum | Sjp_0205390 | IPR011993,Pleckstrin homology-type;IPR000697,EVH1,domain-containing |
Schistosoma mansoni | Smp_082780 | wiskott-aldrich syndrome protein |
Schmidtea mediterranea | mk4.009748.04 | |
Schmidtea mediterranea | mk4.008632.02 | |
Schmidtea mediterranea | mk4.020549.00 | |
Schmidtea mediterranea | mk4.010220.00 | |
Trichomonas vaginalis | TVAG_496150 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_283280 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C07G1.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C07G1.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C07G1.4 | Caenorhabditis elegans | sterile | wormbase |
YOR181W | Saccharomyces cerevisiae | inviable | yeastgenome |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Neural Wiskott-Aldrich syndrome protein | Compounds | References |