pI: 5.8692 |
Length (AA): 507 |
MW (Da): 57439 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127272)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G29880 | glycyl-tRNA synthetase / glycine--tRNA ligase |
Babesia bovis | BBOV_I003770 | glycyl-tRNA synthetase, putative |
Brugia malayi | Bm1_23170 | glycyl-tRNA synthetase |
Candida albicans | CaO19.8067 | glycyl-tRNA synthase |
Candida albicans | CaO19.437 | glycyl-tRNA synthase |
Caenorhabditis elegans | CELE_T10F2.1 | Protein GARS-1, isoform B |
Cryptosporidium hominis | Chro.80123 | glycyl-tRNA synthetase |
Cryptosporidium parvum | cgd8_1030 | glycyl-tRNA synthetase |
Dictyostelium discoideum | DDB_G0284583 | glycine-tRNA ligase |
Drosophila melanogaster | Dmel_CG6778 | Glycyl-tRNA synthetase |
Echinococcus granulosus | EgrG_000976400 | glycyl tRNA synthetase |
Entamoeba histolytica | EHI_073460 | glycyl-tRNA synthetase, putative |
Echinococcus multilocularis | EmuJ_000976400 | glycyl tRNA synthetase |
Giardia lamblia | GL50803_9011 | Glycyl-tRNA synthetase |
Homo sapiens | ENSG00000106105 | glycyl-tRNA synthetase |
Leishmania braziliensis | LbrM.35.4070 | glycyl tRNA synthetase, putative |
Leishmania donovani | LdBPK_364030.1 | glycyl tRNA synthetase, putative |
Leishmania infantum | LinJ.36.4030 | glycyl tRNA synthetase, putative |
Leishmania major | LmjF.36.3840 | glycyl tRNA synthetase, putative |
Leishmania mexicana | LmxM.36.3840 | glycyl tRNA synthetase, putative |
Loa Loa (eye worm) | LOAG_05879 | glycyl-tRNA synthetase |
Mycobacterium leprae | ML0826 | PROBABLE GLYCYL-tRNA SYNTHETASE GLYS (GLYCINE--tRNA LIGASE) (GLYRS) |
Mus musculus | ENSMUSG00000029777 | glycyl-tRNA synthetase |
Mycobacterium tuberculosis | Rv2357c | Probable glycyl-tRNA synthetase GlyS (glycine--tRNA ligase) (GLYRS) |
Mycobacterium ulcerans | MUL_3610 | glycyl-tRNA synthetase |
Neospora caninum | NCLIV_029970 | TRNA synthetase Gly, related |
Oryza sativa | 4346171 | Os08g0538000 |
Plasmodium berghei | PBANKA_1022800 | glycine--tRNA ligase, putative |
Plasmodium falciparum | PF3D7_1420400 | glycine--tRNA ligase |
Plasmodium knowlesi | PKNH_1337600 | glycine--tRNA ligase, putative |
Plasmodium vivax | PVX_085460 | glycine--tRNA ligase, putative |
Plasmodium yoelii | PY01198 | glycyl-tRNA synthetase |
Saccharomyces cerevisiae | YBR121C | glycine--tRNA ligase |
Saccharomyces cerevisiae | YPR081C | putative glycine--tRNA ligase |
Schistosoma japonicum | Sjp_0311960 | ko:K01880 glycyl-tRNA synthetase, class II [EC6.1.1.14C], putative |
Schistosoma japonicum | Sjp_0039430 | Glycyl-tRNA synthetase, putative |
Schistosoma mansoni | Smp_040800 | glycyl-tRNA synthetase |
Schmidtea mediterranea | mk4.003880.05 | GlycineALQ-tRNA ligase |
Trypanosoma brucei gambiense | Tbg972.11.10820 | glycyl-tRNA synthetase, putative |
Trypanosoma brucei | Tb927.11.9640 | glycyl-tRNA synthetase, putative |
Trypanosoma congolense | TcIL3000.11.10140 | glycyl-tRNA synthetase, putative |
Trypanosoma cruzi | TcCLB.504017.79 | glycyl-tRNA synthetase, putative |
Trypanosoma cruzi | TcCLB.511229.110 | glycyl-tRNA synthetase, putative |
Toxoplasma gondii | TGME49_256990 | glycyl-tRNA synthetase |
Treponema pallidum | TP0672 | glycyl-tRNA synthetase |
Theileria parva | TP01_0460 | glycyl-tRNA synthetase, putative |
Trichomonas vaginalis | TVAG_398690 | glycyl-tRNA synthetase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.1400 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.1400 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.1400 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb11.01.1400 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T10F2.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T10F2.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T10F2.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T10F2.1 | Caenorhabditis elegans | sterile | wormbase |
YBR121C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1022800 | Plasmodium berghei | Essential | plasmo |
TGME49_256990 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.