pI: 6.6893 |
Length (AA): 322 |
MW (Da): 36823 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
37 | 322 | 1vjr (A) | 0 | 255 | 26.00 | 0 | 1 | 1.14 | -1.16 |
45 | 322 | 1zjj (A) | 3 | 257 | 37.00 | 0 | 1 | 1.39 | -1.52 |
32 | 322 | 2x4d (A) | 0 | 261 | 21.00 | 0.018 | 1 | 1.03593 | 0.23 |
42 | 321 | 1vjr (A) | 4 | 254 | 28.00 | 0 | 1 | 1.15677 | -0.45 |
48 | 322 | 1zjj (A) | 6 | 257 | 38.00 | 0 | 1 | 1.29924 | -0.63 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, early trophozoite, Oocyst, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | late trophozoite, Sporozoite. | PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 40 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | intra-erythrocytic - 48 hs, Female Gametocyte, Male Gametocyte. | Otto TD Lasonder E |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_127049)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G47760 | 2-phosphoglycolate phosphatase 2 |
Arabidopsis thaliana | AT5G36790 | Haloacid dehalogenase-like hydrolase (HAD) superfamily protein |
Arabidopsis thaliana | AT5G36700 | 2-phosphoglycolate phosphatase 1 |
Brugia malayi | Bm1_19505 | haloacid dehalogenase-like hydrolase family protein |
Candida albicans | CaO19.4172 | one of three genes similar to S. cerevisiae PHO13 (YDL236W) p-nitrophenyl phosphatase |
Candida albicans | CaO19.4444 | one of three genes similar to S. cerevisiae PHO13 (YDL236W) p-nitrophenyl phosphatase |
Candida albicans | CaO19.11924 | one of three genes similar to S. cerevisiae PHO13 (YDL236W) p-nitrophenyl phosphatase |
Candida albicans | CaO19.11648 | one of three genes similar to S. cerevisiae PHO13 (YDL236W) p-nitrophenyl phosphatase |
Caenorhabditis elegans | CELE_K09H11.7 | Protein K09H11.7 |
Caenorhabditis elegans | CELE_C53A3.2 | Protein C53A3.2 |
Caenorhabditis elegans | CELE_F44E7.2 | Protein F44E7.2 |
Dictyostelium discoideum | DDB_G0284737 | hypothetical protein |
Drosophila melanogaster | Dmel_CG5567 | CG5567 gene product from transcript CG5567-RA |
Escherichia coli | b0675 | UMP phosphatase |
Echinococcus granulosus | EgrG_001078600 | 4 nitrophenylphosphatase |
Echinococcus multilocularis | EmuJ_001078600 | 4 nitrophenylphosphatase |
Homo sapiens | ENSG00000241360 | pyridoxal (pyridoxine, vitamin B6) phosphatase |
Homo sapiens | ENSG00000184207 | phosphoglycolate phosphatase |
Leishmania braziliensis | LbrM.31.2620 | p-nitrophenylphosphatase, putative |
Leishmania donovani | LdBPK_312410.1 | p-nitrophenylphosphatase, putative |
Leishmania infantum | LinJ.31.2420 | p-nitrophenylphosphatase, putative |
Leishmania infantum | LinJ.31.2410 | p-nitrophenylphosphatase, putative |
Leishmania major | LmjF.31.2340 | p-nitrophenylphosphatase, putative |
Leishmania mexicana | LmxM.30.2340 | p-nitrophenylphosphatase, putative |
Loa Loa (eye worm) | LOAG_02900 | 4-nitrophenylphosphatase |
Mus musculus | ENSMUSG00000043445 | phosphoglycolate phosphatase |
Mus musculus | ENSMUSG00000022436 | pyridoxal (pyridoxine, vitamin B6) phosphatase |
Mycobacterium tuberculosis | Rv1692 | Probable phosphatase |
Mycobacterium ulcerans | MUL_1681 | phosphatase |
Neospora caninum | NCLIV_042340 | 4-nitrophenylphosphatase, putative |
Neospora caninum | NCLIV_004110 | hypothetical protein |
Oryza sativa | 9271010 | Os12g0420000 |
Oryza sativa | 4336245 | Os04g0490800 |
Oryza sativa | 4346547 | Os09g0261300 |
Onchocerca volvulus | OVOC11831 | Putative phosphoglycolate\/pyridoxal phosphate phosphatase |
Plasmodium berghei | PBANKA_1421300 | 4-nitrophenylphosphatase, putative |
Plasmodium falciparum | PF3D7_0715000 | 4-nitrophenylphosphatase |
Plasmodium knowlesi | PKNH_1424000 | 4-nitrophenylphosphatase, putative |
Plasmodium vivax | PVX_122960 | 4-nitrophenylphosphatase, putative |
Plasmodium yoelii | PY01300 | Phosphoglycolate phosphatase, eukaryotic |
Saccharomyces cerevisiae | YDL236W | Pho13p |
Schistosoma japonicum | Sjp_0212930 | ko:K01101 4-nitrophenyl phosphatase [EC3.1.3.41], putative |
Schistosoma mansoni | Smp_030220 | phosphoglycolate/pyridoxal phosphate phosphatase |
Schmidtea mediterranea | mk4.006053.03 | Putative phosphoglycolate/pyridoxal phosphate phosphatase |
Schmidtea mediterranea | mk4.016915.00 | Putative phosphoglycolate/pyridoxal phosphate phosphatase |
Trypanosoma brucei gambiense | Tbg972.8.7750 | p-nitrophenylphosphatase, putative,phosphoglycolate phosphatase, putative |
Trypanosoma brucei | Tb927.8.7510 | p-nitrophenylphosphatase, putative |
Trypanosoma congolense | TcIL3000_0_02570 | p-nitrophenylphosphatase, putative |
Trypanosoma congolense | TcIL3000_8_7900 | p-nitrophenylphosphatase, putative |
Trypanosoma congolense | TcIL3000_8_7760 | p-nitrophenylphosphatase, putative |
Trypanosoma cruzi | TcCLB.511439.100 | p-nitrophenylphosphatase, putative |
Trypanosoma cruzi | TcCLB.509261.10 | p-nitrophenylphosphatase, putative |
Toxoplasma gondii | TGME49_209870 | HAD hydrolase, family IIA protein |
Trichomonas vaginalis | TVAG_434390 | pyridoxal-5-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_247920 | 4-nitrophenylphosphatase, putative |
Trichomonas vaginalis | TVAG_319310 | pyridoxal-5-phosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_391630 | 4-nitrophenylphosphatase, putative |
Trichomonas vaginalis | TVAG_382280 | 4-nitrophenylphosphatase, putative |
Trichomonas vaginalis | TVAG_242660 | 4-nitrophenylphosphatase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1721 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.8.7510 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.7510 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.7510 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.7510 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0675 | Escherichia coli | non-essential | goodall |
TGME49_209870 | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
2 literature references were collected for this gene.