Detailed view for TVAG_341370

Basic information

TDR Targets ID: 859358
Trichomonas vaginalis, Esterase, putative
Source Database / ID: 

pI: 8.5734 | Length (AA): 293 | MW (Da): 34220 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07859   alpha/beta hydrolase fold

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131762)

Species Accession Gene Product
Mycobacterium leprae ML0314c   Possible lipase LipU
Mycobacterium tuberculosis Rv2385   Putative acetyl hydrolase MbtJ
Mycobacterium tuberculosis Rv3084   Probable acetyl-hydrolase/esterase LipR
Mycobacterium tuberculosis Rv1076   Possible lipase LipU
Mycobacterium tuberculosis Rv3097c   PE-PGRS family protein, triacylglycerol lipase LipY (esterase/lipase) (triglyceride lipase) (tributyrase)
Mycobacterium tuberculosis Rv3487c   Probable esterase/lipase LipF
Mycobacterium ulcerans MUL_2832   lipase LipU
Mycobacterium ulcerans MUL_3067   hypothetical protein
Mycobacterium ulcerans MUL_3642   acetyl hydrolase MbtJ
Mycobacterium ulcerans MUL_0204   lipase LipU
Neospora caninum NCLIV_066210   esterase, putative
Toxoplasma gondii TGME49_250360   alpha/beta hydrolase fold domain-containing protein
Treponema pallidum TP0935   N-acetylphosphinothricin-tripetide-deacetylase
Trichomonas vaginalis TVAG_222050   conserved hypothetical protein
Trichomonas vaginalis TVAG_047290   Esterase, putative
Trichomonas vaginalis TVAG_341370   Esterase, putative
Trichomonas vaginalis TVAG_276160   Esterase, putative

Essentiality

TVAG_341370 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3137 Mycobacterium tuberculosis non-essential nmpdr
mtu2426 Mycobacterium tuberculosis non-essential nmpdr
TGME49_250360 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_341370 (Trichomonas vaginalis), Esterase, putative
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