pI: 7.3314 |
Length (AA): 453 |
MW (Da): 51645 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_126891)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G31760 | putative E3 ubiquitin-protein ligase ARI10 |
Arabidopsis thaliana | AT2G31770 | putative E3 ubiquitin-protein ligase ARI9 |
Arabidopsis thaliana | AT2G16090 | putative E3 ubiquitin-protein ligase ARI2 |
Arabidopsis thaliana | AT3G27710 | putative E3 ubiquitin-protein ligase ARI3 |
Arabidopsis thaliana | AT1G65430 | putative E3 ubiquitin-protein ligase ARI8 |
Arabidopsis thaliana | AT1G05890 | putative E3 ubiquitin-protein ligase ARI5 |
Arabidopsis thaliana | AT2G31780 | putative E3 ubiquitin-protein ligase ARI11 |
Arabidopsis thaliana | AT2G31510 | putative E3 ubiquitin-protein ligase ARI7 |
Arabidopsis thaliana | AT3G27720 | IBR domain containing protein |
Arabidopsis thaliana | AT4G34370 | putative E3 ubiquitin-protein ligase ARI1 |
Brugia malayi | Bm1_36320 | Ariadne-2 protein |
Brugia malayi | Bm1_07850 | ubiquitin-conjugating enzyme E2-binding protein 1, putative |
Candida albicans | CaO19.7224 | potential IBR-type zinc finger protein similar to S. cerevisiae YKR017C |
Caenorhabditis elegans | CELE_C27A12.6 | Protein C27A12.6 |
Caenorhabditis elegans | CELE_Y73F8A.34 | Protein TAG-349, isoform B |
Caenorhabditis elegans | CELE_C27A12.7 | Protein C27A12.7, isoform B |
Caenorhabditis elegans | CELE_T12E12.1 | Protein T12E12.1 |
Caenorhabditis elegans | CELE_C27A12.8 | Protein ARI-1 |
Dictyostelium discoideum | DDB_G0286961 | C3HC4-type zinc finger-containing protein |
Dictyostelium discoideum | DDB_G0275145 | hypothetical protein |
Dictyostelium discoideum | DDB_G0278981 | TRIAD1 protein |
Drosophila melanogaster | Dmel_CG5709 | ariadne 2 |
Drosophila melanogaster | Dmel_CG5659 | ariadne |
Drosophila melanogaster | Dmel_CG12362 | CG12362 gene product from transcript CG12362-RB |
Echinococcus granulosus | EgrG_001177850 | protein ariadne 2 |
Echinococcus granulosus | EgrG_000057300 | Zinc finger C6HC type |
Entamoeba histolytica | EHI_096780 | zinc finger protein, putative |
Entamoeba histolytica | EHI_134790 | zinc finger protein, putative |
Entamoeba histolytica | EHI_122760 | zinc finger protein, putative |
Echinococcus multilocularis | EmuJ_001177850 | protein ariadne 2 |
Echinococcus multilocularis | EmuJ_000057300 | Zinc finger, C6HC type |
Homo sapiens | ENSG00000177479 | ariadne RBR E3 ubiquitin protein ligase 2 |
Homo sapiens | 25820 | ariadne RBR E3 ubiquitin protein ligase 1 |
Leishmania braziliensis | LbrM.30.2120 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_302180.1 | E3 ubiquitin-protein ligase, putative |
Leishmania infantum | LinJ.30.2180 | hypothetical protein, conserved |
Leishmania major | LmjF.30.2170 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.29.2170 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04897 | ariadne-2 protein |
Loa Loa (eye worm) | LOAG_08307 | hypothetical protein |
Mus musculus | ENSMUSG00000064145 | ariadne homolog 2 (Drosophila) |
Mus musculus | ENSMUSG00000025234 | ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) |
Neospora caninum | NCLIV_050310 | hypothetical protein |
Oryza sativa | 4332164 | Os03g0233500 |
Oryza sativa | 4346186 | Os08g0540300 |
Oryza sativa | 4336253 | Os04g0492100 |
Oryza sativa | 4347840 | Os09g0559100 |
Oryza sativa | 4347561 | Os09g0513800 |
Oryza sativa | 4347839 | Os09g0559000 |
Plasmodium berghei | PBANKA_0402400 | IBR domain protein, putative |
Plasmodium falciparum | PF3D7_0303800 | IBR domain protein, putative |
Plasmodium knowlesi | PKNH_0839300 | IBR domain protein, putative |
Plasmodium vivax | PVX_119315 | hypothetical protein, conserved |
Plasmodium yoelii | PY00504 | putative IBR domain protein |
Saccharomyces cerevisiae | YKR017C | Hel1p |
Schistosoma japonicum | Sjp_0027660 | ko:K01931 ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 [EC:6.3.2.19], putative |
Schistosoma japonicum | Sjp_0219810 | ko:K01931 ariadne 2 [EC:6.3.2.19], putative |
Schistosoma mansoni | Smp_130600 | ariadne-1 protein homolog (ari-1) (ubiquitin-conjugating enzyme E2-binding protein 1) |
Schistosoma mansoni | Smp_150890 | ariadne-2 protein homolog (ari-2) |
Schmidtea mediterranea | mk4.000681.09 | Probable protein ariadne-2 |
Schmidtea mediterranea | mk4.009160.01 | |
Schmidtea mediterranea | mk4.008683.00 | Putative ariadne-1 protein homolog |
Trypanosoma brucei gambiense | Tbg972.6.3550 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.6.3780 | E3 ubiquitin-protein ligase, putative |
Trypanosoma congolense | TcIL3000_0_04540 | RING finger protein, putative |
Trypanosoma cruzi | TcCLB.511745.30 | E3 ubiquitin-protein ligase, putative |
Toxoplasma gondii | TGME49_235980 | ARIADNE family protein |
Trichomonas vaginalis | TVAG_074660 | ariadne RING finger, putative |
Trichomonas vaginalis | TVAG_373620 | ankyrin repeat and ibr domain containing protein, putative |
Trichomonas vaginalis | TVAG_074680 | ariadne RING finger, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.3780 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.3780 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.3780 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.3780 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0402400 | Plasmodium berghei | Dispensable | plasmo |
TGME49_235980 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.