Detailed view for TVAG_090900

Basic information

TDR Targets ID: 860709
Trichomonas vaginalis, Rab7, putative
Source Database / ID: 

pI: 8.2605 | Length (AA): 194 | MW (Da): 22554 | Paralog Number: 7

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  
GO:0003924   GTPase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129894)

Species Accession Gene Product
Brugia malayi Bm1_25700   ras-related protein Rab-21
Caenorhabditis elegans CELE_T01B7.3   Protein RAB-21
Dictyostelium discoideum DDB_G0286553   Rab GTPase
Drosophila melanogaster Dmel_CG17515   CG17515 gene product from transcript CG17515-RD
Entamoeba histolytica EHI_129330   Rab family GTPase
Homo sapiens 23011   RAB21, member RAS oncogene family
Leishmania braziliensis LbrM.21.0870   small GTPase, putative,similar to Ras-related protein Rab-21
Leishmania donovani LdBPK_210870.1   ras-related protein Rab21, putative
Leishmania infantum LinJ.21.0870   small GTPase, putative,similar to Ras-related protein Rab-21
Leishmania major LmjF.21.0790   small GTPase, putative,similar to Ras-related protein Rab-21
Leishmania mexicana LmxM.21.0790   small GTPase, putative,similar to Ras-related protein Rab-21
Loa Loa (eye worm) LOAG_08070   hypothetical protein
Mus musculus ENSMUSG00000020132   RAB21, member RAS oncogene family
Oryza sativa 4338469   Os05g0341600
Onchocerca volvulus OVOC13477  
Schmidtea mediterranea mk4.019676.00  
Schmidtea mediterranea mk4.000314.13  
Trypanosoma brucei gambiense Tbg972.10.1790   small GTPase, putative,Ras-related protein, putative
Trypanosoma brucei Tb927.10.1520   ras-related protein Rab21, putative
Trypanosoma congolense TcIL3000_10_1320   ras-related protein Rab21, putative
Trypanosoma cruzi TcCLB.506619.49   ras-related protein Rab21, putative
Trypanosoma cruzi TcCLB.506977.130   ras-related protein Rab21, putative
Trypanosoma cruzi TcCLB.509247.20   ras-related protein Rab21, putative
Trypanosoma cruzi TcCLB.511191.19   ras-related protein Rab21, putative
Trichomonas vaginalis TVAG_286400   Rab22, putative
Trichomonas vaginalis TVAG_090900   Rab7, putative
Trichomonas vaginalis TVAG_015270   small GTPase rabh, putative
Trichomonas vaginalis TVAG_179790   RAC GTPase, putative
Trichomonas vaginalis TVAG_101480   RAB, putative
Trichomonas vaginalis TVAG_080400   Rabx31 protein, putative
Trichomonas vaginalis TVAG_371280   Rab2, putative
Trichomonas vaginalis TVAG_454230   Rab15, 13, 10, 1, 35, 5, and, putative

Essentiality

TVAG_090900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.1520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.1520 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.1520 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T01B7.3 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_090900 (Trichomonas vaginalis), Rab7, putative
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