Detailed view for TVAG_045310

Basic information

TDR Targets ID: 862837
Trichomonas vaginalis, myo-inositol-1 phosphate synthase, putative
Source Database / ID: 

pI: 6.2298 | Length (AA): 499 | MW (Da): 56017 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01658   Myo-inositol-1-phosphate synthase
PF07994   Myo-inositol-1-phosphate synthase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004512   inositol-3-phosphate synthase activity  
GO:0008654   phospholipid biosynthetic process  
GO:0006021   inositol biosynthetic process  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128316)

Species Accession Gene Product
Arabidopsis thaliana AT2G22240   myo-inositol-1-phosphate synthase 2
Arabidopsis thaliana AT4G39800   myo-inositol-1-phosphate synthase 1
Arabidopsis thaliana AT5G10170   myo-inositol-1-phosphate synthase
Candida albicans CaO19.7585   similar to S. cerevisiae INO1 (YJL153C) inositol-1-phosphate synthase
Caenorhabditis elegans CELE_VF13D12L.1   Protein INOS-1
Dictyostelium discoideum DDB_G0285505   inositol-3-phosphate synthase
Drosophila melanogaster Dmel_CG11143   CG11143 gene product from transcript CG11143-RA
Entamoeba histolytica EHI_070720   L-myo-inositol-1-phosphate synthase
Giardia lamblia GL50803_17579   Inositol-3-phosphate synthase
Homo sapiens ENSG00000105655   inositol-3-phosphate synthase 1
Leishmania braziliensis LbrM.14.1540   myo-inositol-1-phosphate synthase,inositol-3-phosphate synthase, putative
Leishmania donovani LdBPK_141450.1   myo-inositol-1-phosphate synthase
Leishmania infantum LinJ.14.1450   myo-inositol-1-phosphate synthase,inositol-3-phosphate synthase, putative
Leishmania major LmjF.14.1360   inositol-3-phosphate synthase
Leishmania mexicana LmxM.14.1360   myo-inositol-1-phosphate synthase
Mus musculus ENSMUSG00000019139   myo-inositol 1-phosphate synthase A1
Mycobacterium ulcerans MUL_1692   myo-inositol-1-phosphate synthase
Oryza sativa 4331917   Os03g0192700
Oryza sativa 4348467   Os10g0369900
Plasmodium berghei PBANKA_1111400   inositol-3-phosphate synthase, putative
Plasmodium falciparum PF3D7_0511800   inositol-3-phosphate synthase
Plasmodium knowlesi PKNH_1021800   inositol-3-phosphate synthase, putative
Plasmodium vivax PVX_080650   inositol-3-phosphate synthase, putative
Plasmodium yoelii PY03995   myo-inositol-1-phosphate synthase
Saccharomyces cerevisiae YJL153C   inositol-3-phosphate synthase INO1
Trypanosoma brucei gambiense Tbg972.10.8690   myo-inositol-1-phosphate synthase, putative
Trypanosoma brucei Tb927.10.7110   inositol-3-phosphate synthase, putative
Trypanosoma congolense TcIL3000_10_6100   myo-inositol-1-phosphate synthase, putative
Trypanosoma cruzi TcCLB.507609.60   inositol-3-phosphate synthase, putative
Trichomonas vaginalis TVAG_476980   myo-inositol-1 phosphate synthase, putative
Trichomonas vaginalis TVAG_045310   myo-inositol-1 phosphate synthase, putative
Trichomonas vaginalis TVAG_476990   myo-inositol-1 phosphate synthase, putative
Trichomonas vaginalis TVAG_407170   myo-inositol-1 phosphate synthase, putative
Trichomonas vaginalis TVAG_358360   myo-inositol-1 phosphate synthase, putative
Trichomonas vaginalis TVAG_292690   myo-inositol-1 phosphate synthase, putative

Essentiality

TVAG_045310 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.7110 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.7110 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.7110 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.7110 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_VF13D12L.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_VF13D12L.1 Caenorhabditis elegans larval lethal wormbase
CELE_VF13D12L.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_045310 (Trichomonas vaginalis), myo-inositol-1 phosphate synthase, putative
Title for this comment
Comment