Detailed view for TVAG_476010

Basic information

TDR Targets ID: 863746
Trichomonas vaginalis, fused toes, putative
Source Database / ID: 

pI: 9.5402 | Length (AA): 182 | MW (Da): 20872 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00179   Ubiquitin-conjugating enzyme

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130909)

Species Accession Gene Product
Brugia malayi Bm1_55035   Ubiquitin-conjugating enzyme family protein
Caenorhabditis elegans CELE_Y69H2.6   Protein UBC-19
Cryptosporidium hominis Chro.20031   hypothetical protein
Cryptosporidium parvum cgd2_240   ubiquitin-conjugating enzyme
Dictyostelium discoideum DDB_G0278075   hypothetical protein
Drosophila melanogaster Dmel_CG16894   CG16894 gene product from transcript CG16894-RA
Drosophila melanogaster Dmel_CG10536   crossbronx
Echinococcus granulosus EgrG_000156800   AKT interacting protein
Echinococcus multilocularis EmuJ_000156800   AKT interacting protein
Homo sapiens ENSG00000166971   AKT interacting protein
Loa Loa (eye worm) LOAG_01487   hypothetical protein
Mus musculus ENSMUSG00000031667   thymoma viral proto-oncogene 1 interacting protein
Neospora caninum NCLIV_024020   ubiquitin-conjugating enzyme domain-containing protein, putative
Plasmodium berghei PBANKA_1457000   ubiquitin-conjugating enzyme E2, putative
Plasmodium falciparum PF3D7_1243700   ubiquitin-conjugating enzyme E2, putative
Plasmodium knowlesi PKNH_1463000   ubiquitin-conjugating enzyme E2, putative
Plasmodium vivax PVX_101085   ubiquitin-conjugating enzyme E2, putative
Plasmodium yoelii PY01211   ubiquitin-conjugating enzyme e2-17 kDa
Schmidtea mediterranea mk4.000287.01  
Toxoplasma gondii TGME49_264050   ubiquitin-conjugating enzyme subfamily protein
Trichomonas vaginalis TVAG_476010   fused toes, putative
Trichomonas vaginalis TVAG_130740   ubiquitin-conjugating enzyme E2, putative

Essentiality

TVAG_476010 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1457000 Plasmodium berghei Dispensable plasmo
TGME49_264050 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_476010 (Trichomonas vaginalis), fused toes, putative
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