Detailed view for TVAG_318950

Basic information

TDR Targets ID: 865856
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 9.7946 | Length (AA): 457 | MW (Da): 50847 | Paralog Number: 9

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07004   Sperm-tail PG-rich repeat

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136632)

Species Accession Gene Product
Leishmania braziliensis LbrM.34.3910   hypothetical protein, conserved
Leishmania donovani LdBPK_353970.1   hypothetical protein, conserved
Leishmania infantum LinJ.35.3970   hypothetical protein, conserved
Leishmania major LmjF.35.3925   hypothetical protein, conserved
Leishmania mexicana LmxM.34.3925   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.9.6630   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.11140   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_31030   Sperm-tail PG-rich repeat, putative
Trypanosoma congolense TcIL3000_9_4590   Sperm-tail PG-rich repeat, putative
Trypanosoma cruzi TcCLB.508461.350   hypothetical protein, conserved
Trichomonas vaginalis TVAG_085630   conserved hypothetical protein
Trichomonas vaginalis TVAG_168970   conserved hypothetical protein
Trichomonas vaginalis TVAG_318950   conserved hypothetical protein
Trichomonas vaginalis TVAG_331890   conserved hypothetical protein
Trichomonas vaginalis TVAG_420380   conserved hypothetical protein
Trichomonas vaginalis TVAG_411370   conserved hypothetical protein
Trichomonas vaginalis TVAG_094420   conserved hypothetical protein
Trichomonas vaginalis TVAG_137890   conserved hypothetical protein
Trichomonas vaginalis TVAG_354130   conserved hypothetical protein
Trichomonas vaginalis TVAG_372730   conserved hypothetical protein

Essentiality

TVAG_318950 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.2450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.2450 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.2450 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb09.211.2450 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_318950 (Trichomonas vaginalis), conserved hypothetical protein
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