pI: 4.6898 |
Length (AA): 329 |
MW (Da): 38037 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129149)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G10840 | translation initiation factor 3 subunit H1 |
Babesia bovis | BBOV_III006660 | conserved hypothetical protein |
Brugia malayi | Bm1_50170 | Mov34/MPN/PAD-1 family protein |
Candida albicans | CaO19.6748 | similar to human translation initiation factor eIF3-gamma-p40 subunit and to S. pombe SPAC821.05 |
Candida albicans | CaO19.14040 | similar to human translation initiation factor eIF3-gamma-p40 subunit and to S. pombe SPAC821.05 |
Caenorhabditis elegans | CELE_C41D11.2 | Protein EIF-3.H |
Cryptosporidium hominis | Chro.70578 | hypothetical protein |
Cryptosporidium parvum | cgd7_5180 | eIF3 gamma/P40 with JAB/PAD domains; translation initiation factor IF-3 subunit 3 |
Dictyostelium discoideum | DDB_G0281153 | Mov34/MPN/PAD-1 family protein |
Drosophila melanogaster | Dmel_CG9124 | Eukaryotic initiation factor 3 p40 subunit |
Echinococcus granulosus | EgrG_000260300 | Mername AA168 protein M67 family |
Echinococcus granulosus | EgrG_000260200 | PQ loop repeat containing protein 2 |
Echinococcus granulosus | EgrG_000117100 | eukaryotic translation initiation factor 3 |
Echinococcus multilocularis | EmuJ_000260300 | Mername AA168 protein (M67 family) |
Echinococcus multilocularis | EmuJ_000260200 | PQ loop repeat containing protein 2 |
Echinococcus multilocularis | EmuJ_000117100 | eukaryotic translation initiation factor 3 |
Homo sapiens | ENSG00000147677 | eukaryotic translation initiation factor 3, subunit H |
Loa Loa (eye worm) | LOAG_06470 | Mov34/MPN/PAD-1 family protein |
Mus musculus | ENSMUSG00000022312 | eukaryotic translation initiation factor 3, subunit H |
Neospora caninum | NCLIV_066600 | DEHA2F06798p, related |
Oryza sativa | 4335611 | Os04g0376500 |
Schistosoma japonicum | Sjp_0216630 | PQ-loop repeat-containing protein 2, putative |
Schistosoma japonicum | Sjp_0305560 | IPR010920,Like-Sm ribonucleoprotein-related, core;IPR001163,Like-Sm ribonucleoprotein, core,domain-containing |
Schistosoma japonicum | Sjp_0209430 | ko:K03247 translation initiation factor eIF-3 subunit 3, putative |
Schistosoma mansoni | Smp_158500 | Mername-AA168 protein (M67 family) |
Schmidtea mediterranea | mk4.009227.00 | Eukaryotic translation initiation factor 3 subunit H |
Schmidtea mediterranea | mk4.002107.01 | Eukaryotic translation initiation factor 3 subunit H |
Toxoplasma gondii | TGME49_251500 | eukaryotic initiation factor-3, subunit 3, putative |
Theileria parva | TP02_0307 | hypothetical protein |
Trichomonas vaginalis | TVAG_105990 | eukaryotic translation initiation factor 3 subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C41D11.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C41D11.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C41D11.2 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_251500 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.