Detailed view for TVAG_105990

Basic information

TDR Targets ID: 867297
Trichomonas vaginalis, eukaryotic translation initiation factor 3 subunit, putative
Source Database / ID: 

pI: 4.6898 | Length (AA): 329 | MW (Da): 38037 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005852   eukaryotic translation initiation factor 3 complex  
GO:0005737   cytoplasm  
GO:0005515   protein binding  
GO:0003743   translation initiation factor activity  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129149)

Species Accession Gene Product
Arabidopsis thaliana AT1G10840   translation initiation factor 3 subunit H1
Babesia bovis BBOV_III006660   conserved hypothetical protein
Brugia malayi Bm1_50170   Mov34/MPN/PAD-1 family protein
Candida albicans CaO19.6748   similar to human translation initiation factor eIF3-gamma-p40 subunit and to S. pombe SPAC821.05
Candida albicans CaO19.14040   similar to human translation initiation factor eIF3-gamma-p40 subunit and to S. pombe SPAC821.05
Caenorhabditis elegans CELE_C41D11.2   Protein EIF-3.H
Cryptosporidium hominis Chro.70578   hypothetical protein
Cryptosporidium parvum cgd7_5180   eIF3 gamma/P40 with JAB/PAD domains; translation initiation factor IF-3 subunit 3
Dictyostelium discoideum DDB_G0281153   Mov34/MPN/PAD-1 family protein
Drosophila melanogaster Dmel_CG9124   Eukaryotic initiation factor 3 p40 subunit
Echinococcus granulosus EgrG_000260300   Mername AA168 protein M67 family
Echinococcus granulosus EgrG_000260200   PQ loop repeat containing protein 2
Echinococcus granulosus EgrG_000117100   eukaryotic translation initiation factor 3
Echinococcus multilocularis EmuJ_000260300   Mername AA168 protein (M67 family)
Echinococcus multilocularis EmuJ_000260200   PQ loop repeat containing protein 2
Echinococcus multilocularis EmuJ_000117100   eukaryotic translation initiation factor 3
Homo sapiens ENSG00000147677   eukaryotic translation initiation factor 3, subunit H
Loa Loa (eye worm) LOAG_06470   Mov34/MPN/PAD-1 family protein
Mus musculus ENSMUSG00000022312   eukaryotic translation initiation factor 3, subunit H
Neospora caninum NCLIV_066600   DEHA2F06798p, related
Oryza sativa 4335611   Os04g0376500
Schistosoma japonicum Sjp_0216630   PQ-loop repeat-containing protein 2, putative
Schistosoma japonicum Sjp_0305560   IPR010920,Like-Sm ribonucleoprotein-related, core;IPR001163,Like-Sm ribonucleoprotein, core,domain-containing
Schistosoma japonicum Sjp_0209430   ko:K03247 translation initiation factor eIF-3 subunit 3, putative
Schistosoma mansoni Smp_158500   Mername-AA168 protein (M67 family)
Schmidtea mediterranea mk4.009227.00   Eukaryotic translation initiation factor 3 subunit H
Schmidtea mediterranea mk4.002107.01   Eukaryotic translation initiation factor 3 subunit H
Toxoplasma gondii TGME49_251500   eukaryotic initiation factor-3, subunit 3, putative
Theileria parva TP02_0307   hypothetical protein
Trichomonas vaginalis TVAG_105990   eukaryotic translation initiation factor 3 subunit, putative

Essentiality

TVAG_105990 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C41D11.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C41D11.2 Caenorhabditis elegans larval lethal wormbase
CELE_C41D11.2 Caenorhabditis elegans slow growth wormbase
TGME49_251500 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_105990 (Trichomonas vaginalis), eukaryotic translation initiation factor 3 subunit, putative
Title for this comment
Comment