Detailed view for TVAG_420180

Basic information

TDR Targets ID: 869307
Trichomonas vaginalis, suppressor of ty, putative
Source Database / ID: 

pI: 5.3372 | Length (AA): 900 | MW (Da): 100283 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00467   KOW motif
PF03439   Early transcription elongation factor of RNA pol II, NGN section

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127919)

Species Accession Gene Product
Arabidopsis thaliana AT4G08350   global transcription factor group A2
Arabidopsis thaliana AT2G34210   transcription elongation factor Spt5
Babesia bovis BBOV_III000200   KOW motif family protein
Brugia malayi Bm1_19900   Micro-fibrillar-associated protein 1 C-terminus containing protein
Candida albicans CaO19.9028   similar to S. cerevisiae SPT5 (YML010W) RNA Pol II transcription elongation factor
Candida albicans CaO19.1453   similar to S. cerevisiae SPT5 (YML010W) RNA Pol II transcription elongation factor
Caenorhabditis elegans CELE_K08E4.1   Protein SPT-5
Cryptosporidium hominis Chro.60534   spt5-like transcription initiation protein
Cryptosporidium parvum cgd6_4650   5kows transcription initiation protein SPT5
Dictyostelium discoideum DDB_G0287661   transcription initiation factor Spt5
Drosophila melanogaster Dmel_CG7626   CG7626 gene product from transcript CG7626-RA
Echinococcus granulosus EgrG_000788800   suppressor of Ty 5
Entamoeba histolytica EHI_187280   transcription initiation factor SPT5, putative
Echinococcus multilocularis EmuJ_000788800   suppressor of Ty 5
Echinococcus multilocularis EmuJ_000011100   transcription elongation factor spt5
Homo sapiens ENSG00000196235   suppressor of Ty 5 homolog (S. cerevisiae)
Leishmania braziliensis LbrM.27.2480   transcription elongation regulator-like protein
Leishmania donovani LdBPK_272220.1   transcription elongation regulator-like protein
Leishmania infantum LinJ.27.2220   transcription elongation regulator-like protein
Leishmania major LmjF.27.2300   transcription elongation regulator-like protein
Leishmania mexicana LmxM.27.2300   transcription elongation regulator-like protein
Loa Loa (eye worm) LOAG_11859   hypothetical protein
Loa Loa (eye worm) LOAG_00211   hypothetical protein
Loa Loa (eye worm) LOAG_00212   hypothetical protein
Mus musculus ENSMUSG00000003435   suppressor of Ty 5
Neospora caninum NCLIV_032830   hypothetical protein
Oryza sativa 9267296   Os02g0772000
Plasmodium berghei PBANKA_0109200   transcription elongation factor SPT5, putative
Plasmodium falciparum PF3D7_0610900   transcription elongation factor SPT5, putative
Plasmodium knowlesi PKNH_1139500   transcription elongation factor SPT5, putative
Plasmodium vivax PVX_113680   transcription elongation factor SPT5, putative
Plasmodium yoelii PY03112   similar to suppressor of Ty 5 homolog
Saccharomyces cerevisiae YML010W   transcription elongation factor SPT5
Schistosoma japonicum Sjp_0020680   expressed protein
Schistosoma japonicum Sjp_0079130   Transcription elongation factor SPT5, putative
Schistosoma mansoni Smp_151070   suppressor of ty
Schmidtea mediterranea mk4.000247.06   Transcription elongation factor SPT5
Schmidtea mediterranea mk4.000247.05  
Schmidtea mediterranea mk4.000339.07   Transcription elongation factor SPT5
Trypanosoma brucei gambiense Tbg.972.2.3050   transcription initiation protein, putative
Trypanosoma brucei Tb927.2.5030   transcription initiation protein, putative
Trypanosoma congolense TcIL3000_2_1190   transcription initiation protein, putative
Trypanosoma cruzi TcCLB.511625.10   transcription initiation protein, putative
Trypanosoma cruzi TcCLB.504741.60   transcription initiation protein, putative
Toxoplasma gondii TGME49_233000   KOW motif domain-containing protein
Theileria parva TP03_0828   transcription factor, putative
Trichomonas vaginalis TVAG_420180   suppressor of ty, putative

Essentiality

TVAG_420180 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.5030 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.2.5030 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.2.5030 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.2.5030 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K08E4.1 Caenorhabditis elegans embryonic arrest wormbase
CELE_K08E4.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_K08E4.1 Caenorhabditis elegans larval arrest wormbase
CELE_K08E4.1 Caenorhabditis elegans slow growth wormbase
CELE_K08E4.1 Caenorhabditis elegans sterile wormbase
YML010W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0109200 Plasmodium berghei Slow plasmo
TGME49_233000 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_420180 (Trichomonas vaginalis), suppressor of ty, putative
Title for this comment
Comment