Detailed view for TVAG_435500

Basic information

TDR Targets ID: 872292
Trichomonas vaginalis, nf kappa B inhibitor I-kappa-B, putative
Source Database / ID: 

pI: 4.8886 | Length (AA): 174 | MW (Da): 19636 | Paralog Number: 47

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00023   Ankyrin repeat
PF12796   Ankyrin repeats (3 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131069)

Species Accession Gene Product
Trichomonas vaginalis TVAG_207330   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_520170   ankyrin repeat domain protein, putative
Trichomonas vaginalis TVAG_507330   conserved hypothetical protein
Trichomonas vaginalis TVAG_607480   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_048570   protein phosphatase 1 regulatory inhibitor subunit 16A, putative
Trichomonas vaginalis TVAG_523140   ankyrin repeat domain protein, putative
Trichomonas vaginalis TVAG_530440   conserved hypothetical protein
Trichomonas vaginalis TVAG_515340   conserved hypothetical protein
Trichomonas vaginalis TVAG_576200   cortactin-binding protein, putative
Trichomonas vaginalis TVAG_508870   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_503520   cortactin-binding protein, putative
Trichomonas vaginalis TVAG_518520   serine/threonine-protein kinase ripk4, putative
Trichomonas vaginalis TVAG_415910   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_164940   ankyrin repeat domain, putative
Trichomonas vaginalis TVAG_503380   fetal globin-inducing factor, putative
Trichomonas vaginalis TVAG_289320   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_534130   conserved hypothetical protein
Trichomonas vaginalis TVAG_435500   nf kappa B inhibitor I-kappa-B, putative
Trichomonas vaginalis TVAG_523690   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_534330   2-5A-dependent ribonuclease, putative
Trichomonas vaginalis TVAG_543280   2-5A-dependent ribonuclease, putative
Trichomonas vaginalis TVAG_521820   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_548870   conserved hypothetical protein
Trichomonas vaginalis TVAG_511320   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_234030   ankyrin repeat domain protein, putative
Trichomonas vaginalis TVAG_442320   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_053640   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_446870   ankyrin repeat domain, putative
Trichomonas vaginalis TVAG_522920   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_435840   conserved hypothetical protein
Trichomonas vaginalis TVAG_506980   tankyrase, putative
Trichomonas vaginalis TVAG_213410   conserved hypothetical protein
Trichomonas vaginalis TVAG_349340   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_603070   conserved hypothetical protein
Trichomonas vaginalis TVAG_105610   ankyrin repeat-rich membrane-spanning protein, putative
Trichomonas vaginalis TVAG_164910   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_598830   conserved hypothetical protein
Trichomonas vaginalis TVAG_587030   serine/threonine-protein kinase ripk4, putative
Trichomonas vaginalis TVAG_402600   tankyrase, putative
Trichomonas vaginalis TVAG_574270   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_479510   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_532580   conserved hypothetical protein
Trichomonas vaginalis TVAG_280220   conserved hypothetical protein
Trichomonas vaginalis TVAG_038110   conserved hypothetical protein
Trichomonas vaginalis TVAG_472020   conserved hypothetical protein
Trichomonas vaginalis TVAG_479520   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_606140   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_399870   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_435500 (Trichomonas vaginalis), nf kappa B inhibitor I-kappa-B, putative
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