Detailed view for TVAG_434530

Basic information

TDR Targets ID: 874561
Trichomonas vaginalis, monocyte to macrophage differentiation protein, putative
Source Database / ID: 

pI: 8.1328 | Length (AA): 214 | MW (Da): 24105 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03006   Haemolysin-III related

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0019835   cytolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129296)

Species Accession Gene Product
Brugia malayi Bm1_41670   Haemolysin-III related family protein
Caenorhabditis elegans CELE_Y71G12B.23   Protein Y71G12B.23, isoform A
Dictyostelium discoideum DDB_G0274283   hypothetical protein
Drosophila melanogaster Dmel_CG4615   CG4615 gene product from transcript CG4615-RA
Escherichia coli b2899   hemolysin III family HylIII inner membrane protein
Echinococcus granulosus EgrG_000094000   Monocyte to macrophage differentiation factor 2
Entamoeba histolytica EHI_080730   hemolysin-3, putative
Echinococcus multilocularis EmuJ_000094000   Monocyte to macrophage differentiation factor 2
Homo sapiens ENSG00000136297   monocyte to macrophage differentiation-associated 2
Homo sapiens ENSG00000108960   monocyte to macrophage differentiation-associated
Loa Loa (eye worm) LOAG_11936   hypothetical protein
Mus musculus ENSMUSG00000003948   monocyte to macrophage differentiation-associated
Mus musculus 75104   monocyte to macrophage differentiation-associated 2
Mycobacterium tuberculosis Rv1085c   Possible hemolysin-like protein
Mycobacterium ulcerans MUL_0194   hemolysin-like protein
Onchocerca volvulus OVOC1547  
Schistosoma japonicum Sjp_0095620   IPR004254,Hly-III related proteins,domain-containing
Schmidtea mediterranea mk4.001984.01  
Treponema pallidum TP1037   hemolysin III (hlyIII)
Trichomonas vaginalis TVAG_434530   monocyte to macrophage differentiation protein, putative

Essentiality

TVAG_434530 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1102 Mycobacterium tuberculosis non-essential nmpdr
b2899 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_434530 (Trichomonas vaginalis), monocyte to macrophage differentiation protein, putative
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