Detailed view for TVAG_115620

Basic information

TDR Targets ID: 874660
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 5.7936 | Length (AA): 692 | MW (Da): 80570 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02204   Vacuolar sorting protein 9 (VPS9) domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128538)

Species Accession Gene Product
Arabidopsis thaliana AT5G09320   vacuolar sorting protein 9 (VPS9) domain protein
Arabidopsis thaliana AT3G19770   guanine nucleotide exchange factor VPS9a
Babesia bovis BBOV_II006960   vacuolar sorting protein 9 (VPS9) domain containing protein
Brugia malayi Bm1_29925   Rab5 GDP/GTP exchange factor
Candida albicans CaO19.5533   ras inhibitor
Candida albicans CaO19.12979   ras inhibitor
Caenorhabditis elegans CELE_Y39A1A.5   Protein RABX-5
Cryptosporidium hominis Chro.80217   hypothetical protein
Cryptosporidium parvum cgd8_1880   Vps9p/ RAB5 like RAB GTpase binding protein involved in vacuolar sorting
Dictyostelium discoideum DDB_G0271844   Phox domain-containing protein
Dictyostelium discoideum DDB_G0285073   vacuolar sorting protein 9 domain-containing protein
Dictyostelium discoideum DDB_G0289495   vacuolar sorting protein 9 domain-containing protein
Drosophila melanogaster Dmel_CG9139   Rabaptin-5-associated exchange factor for Rab5 ortholog (H. sapiens)
Echinococcus granulosus EgrG_000885100   rab gdp:gtp exchange factor
Echinococcus multilocularis EmuJ_000885100   rab gdp:gtp exchange factor
Homo sapiens ENSG00000154710   RAB guanine nucleotide exchange factor (GEF) 1
Loa Loa (eye worm) LOAG_06089   Rab5 GDP/GTP exchange factor
Mus musculus ENSMUSG00000025340   RAB guanine nucleotide exchange factor (GEF) 1
Neospora caninum NCLIV_030800   ADL349Wp, related
Oryza sativa 4332330   Os03g0262900
Oryza sativa 4334742   Os03g0842700
Plasmodium berghei PBANKA_0715000   vacuolar protein sorting-associated protein 9, putative
Plasmodium falciparum PF3D7_0815800   vacuolar protein sorting-associated protein 9, putative
Plasmodium knowlesi PKNH_0504600   vacuolar protein sorting-associated protein 9, putative
Plasmodium vivax PVX_089615   vacuolar protein sorting-associated protein 9, putative
Plasmodium yoelii PY00538   hypothetical protein
Saccharomyces cerevisiae YML097C   Vps9p
Schistosoma japonicum Sjp_0016280   Rab5 GDP/GTP exchange factor, putative
Schistosoma mansoni Smp_145180   rab GDP/GTP exchange factor
Schmidtea mediterranea mk4.000130.10  
Schmidtea mediterranea mk4.000130.11  
Toxoplasma gondii TGME49_230140   vacuolar sorting protein 9 (vps9) domain-containing protein
Theileria parva TP02_0669   hypothetical protein
Trichomonas vaginalis TVAG_115620   conserved hypothetical protein

Essentiality

TVAG_115620 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0715000 Plasmodium berghei Essential plasmo
TGME49_230140 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_115620 (Trichomonas vaginalis), conserved hypothetical protein
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