Detailed view for TVAG_157000

Basic information

TDR Targets ID: 875133
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 8.0205 | Length (AA): 355 | MW (Da): 42767 | Paralog Number: 8

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04724   Glycosyltransferase family 17

Gene Ontology

Mouse over links to read term descriptions.
GO:0003830   beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity  
GO:0016020   membrane  
GO:0006487   protein amino acid N-linked glycosylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130586)

Species Accession Gene Product
Arabidopsis thaliana AT3G27540   beta-1,4-N-acetylglucosaminyltransferase family protein
Arabidopsis thaliana AT3G01620   beta-1,4-N-acetylglucosaminyltransferase family protein
Arabidopsis thaliana AT2G13290   beta-1,4-N-acetylglucosaminyltransferase-like protein
Arabidopsis thaliana AT5G14480   beta-1,4-N-acetylglucosaminyltransferase family protein
Arabidopsis thaliana AT1G67880   beta-1,4-N-acetylglucosaminyltransferase like protein
Arabidopsis thaliana AT1G12990   beta-1,4-N-acetylglucosaminyltransferase family protein
Drosophila melanogaster Dmel_CG31849   CG31849 gene product from transcript CG31849-RA
Homo sapiens ENSG00000128268   mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
Mus musculus ENSMUSG00000042428   mannoside acetylglucosaminyltransferase 3
Oryza sativa 4352772   Os12g0611900
Oryza sativa 4336162   Os04g0477500
Oryza sativa 4329854   Os02g0595100
Oryza sativa 4329853   Os02g0594900
Trichomonas vaginalis TVAG_331480   conserved hypothetical protein
Trichomonas vaginalis TVAG_183750   conserved hypothetical protein
Trichomonas vaginalis TVAG_028310   conserved hypothetical protein
Trichomonas vaginalis TVAG_185990   conserved hypothetical protein
Trichomonas vaginalis TVAG_157000   conserved hypothetical protein
Trichomonas vaginalis TVAG_523200   conserved hypothetical protein
Trichomonas vaginalis TVAG_274320   conserved hypothetical protein
Trichomonas vaginalis TVAG_365410   conserved hypothetical protein
Trichomonas vaginalis TVAG_010270   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0133 1 1
0.0133 1 1
0.0836 1 1
0.086 1 1
0.0853 0.9607 1
0.0694 1 1
0.0865 1 1
0.0859 1 1
0.071 1 1
0.0593 1 1
0.0133 0.5163 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_157000 (Trichomonas vaginalis), conserved hypothetical protein
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