Detailed view for TVAG_389920

Basic information

TDR Targets ID: 876790
Trichomonas vaginalis, CAMK family protein kinase
Source Database / ID: 

pI: 8.567 | Length (AA): 375 | MW (Da): 43466 | Paralog Number: 41

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF12330   Haspin like kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129098)

Species Accession Gene Product
Candida albicans CaO19.11993   potential serine/threonine protein kinase similar to S. cerevisiae YPL150W
Candida albicans CaO19.4518   potential serine/threonine protein kinase similar to S. cerevisiae YPL150W
Caenorhabditis elegans CELE_F58H12.1   Protein KIN-29
Entamoeba histolytica EHI_155280   serine/threonine- protein kinase DCAMKL3, putative
Entamoeba histolytica EHI_092530   protein kinase, putative
Plasmodium berghei PBANKA_1318000   serine/threonine protein kinase KIN, putative
Plasmodium yoelii PY06885   serine/threonine-protein kinase
Saccharomyces cerevisiae YPL150W   non-specific serine/threonine protein kinase
Schmidtea mediterranea mk4.007384.00  
Schmidtea mediterranea mk4.005840.03   Protein kinase C-like 3
Schmidtea mediterranea mk4.010587.00  
Schmidtea mediterranea mk4.001873.07   GH28523p
Trichomonas vaginalis TVAG_229590   CAMK family protein kinase
Trichomonas vaginalis TVAG_197160   CAMK family protein kinase
Trichomonas vaginalis TVAG_310870   CAMK family protein kinase
Trichomonas vaginalis TVAG_303170   CAMK family protein kinase
Trichomonas vaginalis TVAG_126240   CAMK family protein kinase
Trichomonas vaginalis TVAG_203870   CAMK family protein kinase
Trichomonas vaginalis TVAG_317670   CAMK family protein kinase
Trichomonas vaginalis TVAG_192420   CAMK family protein kinase
Trichomonas vaginalis TVAG_167070   CAMK family protein kinase
Trichomonas vaginalis TVAG_143260   CAMK family protein kinase
Trichomonas vaginalis TVAG_498970   CAMK family protein kinase
Trichomonas vaginalis TVAG_487960   AGC family protein kinase
Trichomonas vaginalis TVAG_346770   CAMK family protein kinase
Trichomonas vaginalis TVAG_274770   CAMK family protein kinase
Trichomonas vaginalis TVAG_273800   CAMK family protein kinase
Trichomonas vaginalis TVAG_036480   CAMK family protein kinase
Trichomonas vaginalis TVAG_147850   CAMK family protein kinase
Trichomonas vaginalis TVAG_090000   CAMK family protein kinase
Trichomonas vaginalis TVAG_089980   AGC family protein kinase
Trichomonas vaginalis TVAG_120320   CAMK family protein kinase
Trichomonas vaginalis TVAG_119370   serine/threonine kinase, putative
Trichomonas vaginalis TVAG_146660   CAMK family protein kinase
Trichomonas vaginalis TVAG_237250   AGC family protein kinase
Trichomonas vaginalis TVAG_389910   CAMK family protein kinase
Trichomonas vaginalis TVAG_357410   CAMK family protein kinase
Trichomonas vaginalis TVAG_212100   CAMK family protein kinase
Trichomonas vaginalis TVAG_031970   CAMK family protein kinase
Trichomonas vaginalis TVAG_452270   AGC family protein kinase
Trichomonas vaginalis TVAG_359080   CAMK family protein kinase
Trichomonas vaginalis TVAG_430050   AGC family protein kinase
Trichomonas vaginalis TVAG_070040   CAMK family protein kinase
Trichomonas vaginalis TVAG_326510   CAMK family protein kinase
Trichomonas vaginalis TVAG_394310   CAMK family protein kinase
Trichomonas vaginalis TVAG_080470   CAMK family protein kinase
Trichomonas vaginalis TVAG_276080   CAMK family protein kinase
Trichomonas vaginalis TVAG_157810   AGC family protein kinase
Trichomonas vaginalis TVAG_204140   CAMK family protein kinase
Trichomonas vaginalis TVAG_389920   CAMK family protein kinase
Trichomonas vaginalis TVAG_139460   CAMK family protein kinase
Trichomonas vaginalis TVAG_379610   CAMK family protein kinase
Trichomonas vaginalis TVAG_224740   CAMK family protein kinase
Trichomonas vaginalis TVAG_468320   CAMK family protein kinase

Essentiality

TVAG_389920 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1318000 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Zea mays Casein kinase II alpha 332 aa 21.6% 305 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 28.8% 264 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 26.3% 315 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 29.9% 284 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 27.7% 285 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 27.7% 191 aa Compounds References
Patiria pectinifera Cdc2 300 aa 28.4% 292 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 22.3% 301 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.0% 288 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0088 0.4477 1
0.0032 0.5 0.5
0.0063 0.7244 0
0.0092 1 0.5
0.0026 0.5 0.5
0.0033 0.5 0.5
0.0061 0.6883 0.5304
0.0067 0.5 0.5
0.0007 0.5 0.5
0.0081 1 0.5
0.0062 0.6935 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0059 1 1
0.0098 0.3242 0.2373
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0042 0.5 0.5
0.0063 1 1
0.0037 1 0.5
0.0039 0.9485 0.5
0.0016 0.5 0.5
0.0003 0.5 0.5
0.0066 0.3101 0.5
0.0039 0.5 0.5
0.0007 0.5 0.5
0.0018 0.5 0.5
0.0033 1 1
0.0091 1 0.5
0.0059 1 1
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0023 0.5 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5
0.0069 0.3067 0.5
0.0008 0.5 0.5
0.0027 1 0.5
0.0064 0.3377 0.5
0.0011 1 0.5
0.0093 0.8828 0.5
0.0012 0.5 0.5
0.0036 0.5 0.5
0.0029 0.5 0.5
0.0056 1 0.5
0.0081 0.5 0.5
0.0022 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TVAG_389920 (Trichomonas vaginalis), CAMK family protein kinase
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