pI: 7.4322 |
Length (AA): 1031 |
MW (Da): 119187 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127751)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G61460 | protein SMC6B |
Arabidopsis thaliana | AT5G07660 | structural maintenance of chromosomes 6A |
Babesia bovis | BBOV_IV000980 | hypothetical protein |
Babesia bovis | BBOV_IV000970 | hypothetical protein |
Brugia malayi | Bm1_42705 | SMC family, C-terminal domain containing protein |
Candida albicans | CaO19_6568 | hypothetical protein |
Candida albicans | CaO19.6568 | potential SMC chromosomal ATPase similar to S. cerevisiae RHC18 (YLR383W) nuclear DNA repair complex ATPase |
Candida albicans | CaO19.13921 | potential SMC chromosomal ATPase similar to S. cerevisiae RHC18 (YLR383W) nuclear DNA repair complex ATPase |
Caenorhabditis elegans | CELE_F54D5.14 | Protein SMC-6 |
Caenorhabditis elegans | CELE_C23H4.6 | Protein C23H4.6, isoform B |
Cryptosporidium hominis | Chro.80351 | hypothetical protein |
Cryptosporidium parvum | cgd8_3010 | Smc ABC ATpase |
Dictyostelium discoideum | DDB_G0288993 | AAA ATPase domain-containing protein |
Drosophila melanogaster | Dmel_CG5524 | java no jive |
Entamoeba histolytica | EHI_180450 | structural maintenance of chromosomes protein |
Entamoeba histolytica | EHI_033700 | RecF/RecN/SMC domain containing protein |
Giardia lamblia | GL50803_7648 | SMC6 protein |
Homo sapiens | ENSG00000163029 | structural maintenance of chromosomes 6 |
Loa Loa (eye worm) | LOAG_05474 | hypothetical protein |
Mus musculus | ENSMUSG00000020608 | structural maintenance of chromosomes 6 |
Neospora caninum | NCLIV_053750 | Smc ABC ATpase, related |
Oryza sativa | 9267891 | Os09g0121000 |
Onchocerca volvulus | OVOC10307 | Structural maintenance of chromosomes protein 6 homolog |
Plasmodium berghei | PBANKA_1240000 | structural maintenance of chromosomes protein 6, putative |
Plasmodium falciparum | PF3D7_0525200 | structural maintenance of chromosomes protein 6, putative |
Plasmodium knowlesi | PKNH_1007600 | structural maintenance of chromosomes protein 6, putative |
Plasmodium vivax | PVX_079985 | hypothetical protein, conserved |
Plasmodium yoelii | PY06788 | hypothetical protein |
Saccharomyces cerevisiae | YLR383W | DNA repair protein SMC6 |
Toxoplasma gondii | TGME49_309400 | RecF/RecN/SMC N terminal domain-containing protein |
Theileria parva | TP01_0122 | hypothetical protein |
Theileria parva | TP01_0120 | hypothetical protein |
Trichomonas vaginalis | TVAG_176480 | DNA repair protein Smc6 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_F54D5.14 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_1240000 | Plasmodium berghei | Essential | plasmo |
TGME49_309400 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.