Detailed view for TVAG_223970

Basic information

TDR Targets ID: 878318
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 9.5521 | Length (AA): 277 | MW (Da): 31418 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13874   Nucleoporin complex subunit 54

Gene Ontology

Mouse over links to read term descriptions.
GO:0005643   nuclear pore  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132391)

Species Accession Gene Product
Brugia malayi Bm1_16460   Probable nucleoporin Nup54
Caenorhabditis elegans CELE_K07F5.13   Protein NPP-1, isoform A
Drosophila melanogaster Dmel_CG8831   Nucleoporin 54kD
Echinococcus granulosus EgrG_000893700   nuclear pore complex protein Nup54
Echinococcus multilocularis EmuJ_000893700   nuclear pore complex protein Nup54
Homo sapiens ENSG00000138750   nucleoporin 54kDa
Loa Loa (eye worm) LOAG_04523   hypothetical protein
Mus musculus ENSMUSG00000034826   nucleoporin 54
Schistosoma japonicum Sjp_0013230   Nucleoporin p54, putative
Schistosoma mansoni Smp_169640   hypothetical protein
Schmidtea mediterranea mk4.001274.02   Nucleoporin p54
Trichomonas vaginalis TVAG_303500   conserved hypothetical protein
Trichomonas vaginalis TVAG_212410   conserved hypothetical protein
Trichomonas vaginalis TVAG_223970   conserved hypothetical protein

Essentiality

TVAG_223970 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K07F5.13 Caenorhabditis elegans embryonic lethal wormbase
CELE_K07F5.13 Caenorhabditis elegans larval arrest wormbase
CELE_K07F5.13 Caenorhabditis elegans larval lethal wormbase
CELE_K07F5.13 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_223970 (Trichomonas vaginalis), conserved hypothetical protein
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