pI: 6.8696 |
Length (AA): 457 |
MW (Da): 52261 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129592)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G65960 | glutamate decarboxylase 2 |
Arabidopsis thaliana | AT2G02010 | glutamate decarboxylase 4 |
Arabidopsis thaliana | AT2G02000 | glutamate decarboxylase 3 |
Arabidopsis thaliana | AT5G17330 | glutamate decarboxylase 1 |
Arabidopsis thaliana | AT3G17760 | glutamate decarboxylase 5 |
Candida albicans | CaO19.1153 | Glutamate decarboxylase |
Candida albicans | CaO19.8745 | Glutamate decarboxylase |
Dictyostelium discoideum | DDB_G0288715 | glutamate decarboxylase |
Dictyostelium discoideum | DDB_G0280199 | glutamate decarboxylase |
Escherichia coli | b1493 | glutamate decarboxylase B, PLP-dependent |
Escherichia coli | b3517 | glutamate decarboxylase A, PLP-dependent |
Mycobacterium tuberculosis | Rv3432c | Probable glutamate decarboxylase GadB |
Mycobacterium ulcerans | MUL_0878 | glutamate decarboxylase |
Oryza sativa | 4332184 | Os03g0236200 |
Oryza sativa | 4335977 | Os04g0447800 |
Oryza sativa | 4333932 | Os03g0720300 |
Oryza sativa | 4335973 | Os04g0447400 |
Oryza sativa | 4345787 | Os08g0465800 |
Saccharomyces cerevisiae | YMR250W | glutamate decarboxylase GAD1 |
Schmidtea mediterranea | mk4.039579.00 | |
Trichomonas vaginalis | TVAG_457250 | group II pyridoxal-5-phosphate decarboxylase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b1493 | Escherichia coli | non-essential | goodall |
b3517 | Escherichia coli | non-essential | goodall |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.