pI: 10.2467 |
Length (AA): 137 |
MW (Da): 16478 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
12 | 105 | 4kzy (K) | 1 | 97 | 59.00 | 0 | 1 | 1.42003 | -0.8 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | gametocyte, late schizont. | PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_127137)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G52650 | 40S ribosomal protein S10-3 |
Arabidopsis thaliana | AT4G25740 | 40S ribosomal protein S10-1 |
Arabidopsis thaliana | AT5G41520 | 40S ribosomal protein S10-2 |
Babesia bovis | BBOV_III009270 | plectin/S10 domain containing protein |
Brugia malayi | Bm1_17195 | 40S ribosomal protein S10 |
Caenorhabditis elegans | CELE_D1007.6 | Protein RPS-10 |
Cryptosporidium hominis | Chro.50097 | ribosomal protein S10 |
Cryptosporidium parvum | cgd5_2780 | 40S ribosomal protein S10 |
Dictyostelium discoideum | DDB_G0286117 | 40S ribosomal protein S10 |
Drosophila melanogaster | Dmel_CG12275 | Ribosomal protein S10a |
Drosophila melanogaster | Dmel_CG14206 | Ribosomal protein S10b |
Echinococcus granulosus | EgrG_000782400 | 40S ribosomal protein S10 |
Entamoeba histolytica | EHI_197030 | 40S ribosomal protein S10, putative |
Echinococcus multilocularis | EmuJ_000782400 | 40S ribosomal protein S10 |
Giardia lamblia | GL50803_10919 | Ribosomal protein S10B |
Homo sapiens | ENSG00000124614 | ribosomal protein S10 |
Homo sapiens | 100529239 | RPS10-NUDT3 readthrough |
Leishmania braziliensis | LbrM.35.1110 | 40S ribosomal protein S10, putative |
Leishmania braziliensis | LbrM.35.1100 | 40S ribosomal protein S10, putative |
Leishmania donovani | LdBPK_361050.1 | 40S ribosomal protein S10, putative |
Leishmania infantum | LinJ.36.1040 | 40S ribosomal protein S10, putative |
Leishmania infantum | LinJ.36.1050 | 40S ribosomal protein S10, putative |
Leishmania major | LmjF.36.0990 | 40S ribosomal protein S10, putative |
Leishmania major | LmjF.36.0980 | 40S ribosomal protein S10, putative |
Leishmania mexicana | LmxM.36.0980 | 40S ribosomal protein S10, putative |
Leishmania mexicana | LmxM.36.0990 | 40S ribosomal protein S10, putative |
Loa Loa (eye worm) | LOAG_07069 | 40S ribosomal protein S10 |
Mus musculus | ENSMUSG00000052146 | ribosomal protein S10 |
Neospora caninum | NCLIV_007110 | hypothetical protein |
Oryza sativa | 4329619 | Os02g0549600 |
Oryza sativa | 4324553 | Os01g0962600 |
Oryza sativa | 4335865 | Os04g0430100 |
Plasmodium berghei | PBANKA_0617200 | 40S ribosomal protein S10, putative |
Plasmodium falciparum | PF3D7_0719700 | 40S ribosomal protein S10, putative |
Plasmodium knowlesi | PKNH_0315100 | 40S ribosomal protein S10, putative |
Plasmodium vivax | PVX_096335 | 40S ribosomal protein S10, putative |
Plasmodium yoelii | PY02462 | ribosomal protein S10 |
Saccharomyces cerevisiae | YMR230W | ribosomal 40S subunit protein S10B |
Saccharomyces cerevisiae | YOR293W | ribosomal 40S subunit protein S10A |
Schistosoma japonicum | Sjp_0103750 | ko:K02947 small subunit ribosomal protein S10e, putative |
Schistosoma mansoni | Smp_066890 | 40S ribosomal protein S10 |
Trypanosoma brucei gambiense | Tbg972.10.6550 | 40S ribosomal protein S10, putative |
Trypanosoma brucei gambiense | Tbg972.10.6570 | 40S ribosomal protein S10, putative |
Trypanosoma brucei | Tb927.10.5370 | 40S ribosomal protein S10, putative |
Trypanosoma brucei | Tb927.10.5360 | 40S ribosomal protein S10, putative |
Trypanosoma congolense | TcIL3000_10_4510 | 40S ribosomal protein S10, putative |
Trypanosoma congolense | TcIL3000_10_4520 | 40S ribosomal protein S10, putative |
Trypanosoma cruzi | TcCLB.506679.150 | 40S ribosomal protein S10, putative |
Trypanosoma cruzi | TcCLB.506679.140 | 40S ribosomal protein S10, putative |
Toxoplasma gondii | TGME49_275810 | ribosomal protein RPS10 |
Theileria parva | TP04_0836 | 40S ribosomal protein S10, putative |
Trichomonas vaginalis | TVAG_120180 | 40S ribosomal protein S10, putative |
Trichomonas vaginalis | TVAG_329340 | 40S ribosomal protein S10, putative |
Trichomonas vaginalis | TVAG_454860 | 40S ribosomal protein S10, putative |
Trichomonas vaginalis | TVAG_371330 | 40S ribosomal protein S10, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.5370 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.5370 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.5370 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.5370 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_D1007.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_D1007.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_D1007.6 | Caenorhabditis elegans | sterile | wormbase |
YOR293W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0617200 | Plasmodium berghei | Essential | plasmo |
TGME49_275810 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.