pI: 6.6914 |
Length (AA): 339 |
MW (Da): 40760 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127450)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G27650 | splicing factor U2af small subunit A |
Arabidopsis thaliana | AT5G42820 | Splicing factor U2af small subunit B |
Babesia bovis | BBOV_IV007810 | U2 splicing factor subunit, putative |
Brugia malayi | Bm1_55710 | U2 small nuclear RNA auxiliary factor small subunit, putative |
Brugia malayi | Bm1_56100 | splicing factor U2AF35 |
Brugia malayi | Bm1_19485 | U2 small nuclear RNA auxiliary factor small subunit, putative |
Candida albicans | CaO19.53 | one of two potential U2 snRNP auxilliary factor small subunits |
Candida albicans | CaO19.11544 | one of two potential U2 snRNP auxilliary factor small subunits |
Candida albicans | CaO19.4062 | one of two potential U2 snRNP auxilliary factor small subunits |
Candida albicans | CaO19.7714 | one of two potential U2 snRNP auxilliary factor small subunits |
Caenorhabditis elegans | CELE_Y116A8C.35 | Protein UAF-2 |
Cryptosporidium hominis | Chro.80598 | U2 snRNP auxiliary factor, small subunit |
Cryptosporidium parvum | cgd8_5240 | U2AG splicing factor U2AF U2snRNP auxilliary factor small subunit CCCh+RRM+CCCh-like |
Dictyostelium discoideum | DDB_G0285077 | CCHC-type zinc finger-containing protein |
Drosophila melanogaster | Dmel_CG3582 | U2 small nuclear riboprotein auxiliary factor 38 |
Echinococcus granulosus | EgrG_000666850 | splicing factor u2af 35 kda subunit |
Entamoeba histolytica | EHI_016140 | U2 snRNP auxiliary factor small subunit, putative |
Entamoeba histolytica | EHI_156380 | U2 snRNP auxiliary factor small subunit, putative |
Echinococcus multilocularis | EmuJ_000666850 | splicing factor u2af 35 kda subunit |
Giardia lamblia | GL50803_16554 | Splicing factor U2AF subunit, putative |
Homo sapiens | ENSG00000275895 | splicing factor U2AF 35 kDa subunit-like |
Homo sapiens | ENSG00000161265 | U2 small nuclear RNA auxiliary factor 1-like 4 |
Homo sapiens | ENSG00000160201 | U2 small nuclear RNA auxiliary factor 1 |
Leishmania braziliensis | LbrM.03.0200 | U2 splicing auxiliary factor, putative |
Leishmania donovani | LdBPK_030180.1 | U2 splicing auxiliary factor, putative |
Leishmania infantum | LinJ.03.0180 | U2 splicing auxiliary factor, putative |
Leishmania major | LmjF.03.0190 | U2 splicing auxiliary factor, putative |
Leishmania mexicana | LmxM.03.0190 | U2 splicing auxiliary factor, putative |
Loa Loa (eye worm) | LOAG_00486 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10291 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02893 | hypothetical protein |
Mus musculus | ENSMUSG00000078765 | U2 small nuclear RNA auxiliary factor 1-like 4 |
Mus musculus | ENSMUSG00000061613 | U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 |
Neospora caninum | NCLIV_050810 | hypothetical protein |
Oryza sativa | 9268567 | Os09g0491756 |
Oryza sativa | 4326323 | Os01g0667800 |
Oryza sativa | 4339621 | Os05g0564200 |
Onchocerca volvulus | OVOC1100 | Splicing factor U2af 38 kDa subunit homolog |
Onchocerca volvulus | OVOC11823 | Splicing factor U2af 38 kDa subunit homolog |
Plasmodium berghei | PBANKA_0928800 | splicing factor U2AF small subunit, putative |
Plasmodium falciparum | PF3D7_1119300 | splicing factor U2AF small subunit, putative |
Plasmodium knowlesi | PKNH_0917000 | splicing factor U2AF small subunit, putative |
Plasmodium vivax | PVX_091600 | splicing factor U2AF small subunit, putative |
Plasmodium yoelii | PY04677 | similar to RIKEN cDNA 2010107D16 gene |
Schistosoma japonicum | Sjp_0208200 | similar to Splicing factor U2AF 35 kDa subunit, putative |
Schistosoma japonicum | Sjp_0208210 | similar to Splicing factor U2AF 35 kDa subunit, putative |
Schistosoma mansoni | Smp_093100 | U2 snRNP auxiliary factor small subunit |
Schmidtea mediterranea | mk4.003864.00 | Splicing factor U2AF 35 kDa subunit |
Schmidtea mediterranea | mk4.000274.08 | Splicing factor U2AF 35 kDa subunit |
Trypanosoma brucei gambiense | Tbg972.10.4040 | U2 splicing auxiliary factor, putative,U2AF35 |
Trypanosoma brucei | Tb927.10.3200 | U2 splicing auxiliary factor, putative |
Trypanosoma congolense | TcIL3000_10_2650 | U2 splicing auxiliary factor, putative |
Trypanosoma cruzi | TcCLB.503577.20 | U2 splicing auxiliary factor, putative |
Trypanosoma cruzi | TcCLB.510943.60 | U2 splicing auxiliary factor, putative |
Toxoplasma gondii | TGME49_236910 | U2 snRNP auxiliary factor, putative |
Theileria parva | TP03_0294 | U2 small nuclear ribonucleoprotein, auxiliary factor, small subunit, putative |
Trichomonas vaginalis | TVAG_045370 | U2 snrnp auxiliary factor, small subunit, putative |
Trichomonas vaginalis | TVAG_302130 | U2 snrnp auxiliary factor, small subunit, putative |
Trichomonas vaginalis | TVAG_216790 | U2 snrnp auxiliary factor, small subunit, putative |
Trichomonas vaginalis | TVAG_171620 | U2 snrnp auxiliary factor, small subunit, putative |
Trichomonas vaginalis | TVAG_404120 | U2 snrnp auxiliary factor, small subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.3200 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.3200 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.3200 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.3200 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y116A8C.35 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_Y116A8C.35 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y116A8C.35 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y116A8C.35 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y116A8C.35 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0928800 | Plasmodium berghei | Essential | plasmo |
TGME49_236910 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.