Detailed view for TVAG_352610

Basic information

TDR Targets ID: 884446
Trichomonas vaginalis, mismatch repair protein Mlh3 (mutL homolog)
Source Database / ID: 

pI: 7.2615 | Length (AA): 462 | MW (Da): 53044 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08676   MutL C terminal dimerisation domain
PF13589   Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

Gene Ontology

Mouse over links to read term descriptions.
GO:0032300   mismatch repair complex  
GO:0005524   ATP binding  
GO:0016887   ATPase activity  
GO:0006298   mismatch repair  
GO:0007131   meiotic recombination  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130552)

Species Accession Gene Product
Arabidopsis thaliana AT4G35520   DNA mismatch repair protein MLH3
Candida albicans CaO19.7257   Mutl-like orf
Dictyostelium discoideum DDB_G0283883   MutL DNA mismatch repair protein
Echinococcus granulosus EgrG_000860550   hypothetical protein
Echinococcus multilocularis EmuJ_000860550   expressed protein
Homo sapiens ENSG00000119684   mutL homolog 3
Mus musculus ENSMUSG00000021245   mutL homolog 3 (E coli)
Oryza sativa 4347792   Os09g0551900
Saccharomyces cerevisiae YPL164C   mismatch repair protein MLH3
Trichomonas vaginalis TVAG_352610   mismatch repair protein Mlh3 (mutL homolog)

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_352610 (Trichomonas vaginalis), mismatch repair protein Mlh3 (mutL homolog)
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