pI: 9.0225 |
Length (AA): 416 |
MW (Da): 46917 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127784)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G60990 | DEAD-box ATP-dependent RNA helicase 10 |
Babesia bovis | BBOV_I004200 | DEAD/DEAH box helicase and helicase conserved C-terminal domain containing protein |
Babesia bovis | BBOV_I004220 | DEAD/DEAH box helicase and helicase conserved C-terminal domain containing protein |
Brugia malayi | Bm1_25080 | ATP-dependent RNA helicase T26G10.1 in chromosome III, putative |
Candida albicans | CaO19.7546 | ATP-dependent RNA helicase |
Caenorhabditis elegans | CELE_T26G10.1 | Protein T26G10.1 |
Cryptosporidium hominis | Chro.40362 | DEAD box protein |
Cryptosporidium parvum | cgd4_3180 | Rrp3p, eIF4A-1-family RNA SFII helicase (DEXDc+HELICc) |
Dictyostelium discoideum | DDB_G0280147 | DEAD/DEAH box helicase |
Drosophila melanogaster | Dmel_CG9253 | CG9253 gene product from transcript CG9253-RA |
Echinococcus granulosus | EgrG_001197500 | ATP dependent RNA helicase DDX47 |
Echinococcus granulosus | EgrG_000505900 | ATP dependent RNA helicase DDX47 |
Entamoeba histolytica | EHI_111040 | DEAD/DEAH box helicase, putative |
Echinococcus multilocularis | EmuJ_000505900 | ATP dependent RNA helicase DDX47 |
Echinococcus multilocularis | EmuJ_001197500 | ATP dependent RNA helicase DDX47 |
Giardia lamblia | GL50803_9119 | ATP-dependent RNA helicase |
Homo sapiens | ENSG00000213782 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 |
Leishmania braziliensis | LbrM.35.2040 | DEAD box RNA helicase, putative |
Leishmania donovani | LdBPK_361930.1 | DEAD box RNA helicase, putative |
Leishmania infantum | LinJ.36.1930 | DEAD box RNA helicase, putative |
Leishmania major | LmjF.36.1850 | DEAD box RNA helicase, putative |
Leishmania mexicana | LmxM.36.1850 | DEAD box RNA helicase, putative |
Loa Loa (eye worm) | LOAG_08140 | ATP-dependent RNA helicase in chromosome III |
Mus musculus | ENSMUSG00000030204 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 |
Neospora caninum | NCLIV_038460 | DEAD box polypeptide 27, related |
Oryza sativa | 4333678 | Os03g0669000 |
Plasmodium berghei | PBANKA_0315100 | ATP-dependent RNA helicase DDX47, putative |
Plasmodium falciparum | PF3D7_0218400 | ATP-dependent RNA helicase DDX47, putative |
Plasmodium knowlesi | PKNH_0402500 | ATP-dependent RNA helicase DDX47, putative |
Plasmodium vivax | PVX_002620 | DEAD/DEAH box helicase, putative |
Plasmodium yoelii | PY01247 | DEAD/DEAH box helicase, putative |
Saccharomyces cerevisiae | YHR065C | RNA-dependent ATPase RRP3 |
Schistosoma japonicum | Sjp_0218700 | ko:K01529 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 [EC:3.6.1.-], putative |
Schistosoma japonicum | Sjp_0118910 | ATP-dependent rRNA helicase RRP3, putative |
Schistosoma japonicum | Sjp_0050650 | Probable ATP-dependent RNA helicase DDX47, putative |
Schistosoma japonicum | Sjp_0108200 | expressed protein |
Schistosoma mansoni | Smp_090440 | DEAD box ATP-dependent RNA helicase |
Schistosoma mansoni | Smp_157660 | DEAD box ATP-dependent RNA helicase |
Schmidtea mediterranea | mk4.065800.00 | DEAD box ATP-dependent RNA helicase, putative |
Schmidtea mediterranea | mk4.021640.00 | DEAD box ATP-dependent RNA helicase, putative |
Schmidtea mediterranea | mk4.005657.01 | DEAD box ATP-dependent RNA helicase, putative |
Schmidtea mediterranea | mk4.000536.05 | Putative ATP-dependent RNA helicase |
Trypanosoma brucei gambiense | Tbg972.10.7670 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma brucei | Tb927.10.6290 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma congolense | TcIL3000_10_5360 | ATP-dependent DEAD/H RNA helicase, putative |
Trypanosoma cruzi | TcCLB.507641.140 | ATP-dependent DEAD/H RNA helicase, putative |
Toxoplasma gondii | TGME49_279330 | DEAD/DEAH box helicase family protein |
Theileria parva | TP02_0728 | ATP-dependent RNA helicase, putative |
Trichomonas vaginalis | TVAG_473950 | DEAD box ATP-dependent RNA helicase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.6290 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6290 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6290 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.6290 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T26G10.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T26G10.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T26G10.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T26G10.1 | Caenorhabditis elegans | sterile | wormbase |
YHR065C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_279330 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.