pI: 6.8891 |
Length (AA): 347 |
MW (Da): 38901 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_207380)
Species | Accession | Gene Product |
---|---|---|
Schmidtea mediterranea | mk4.002297.05 | |
Trichomonas vaginalis | TVAG_074590 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_336270 | CMGC family protein kinase |
Trichomonas vaginalis | TVAG_498910 | CMGC family protein kinase |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 41.9% | 160 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 34.2% | 298 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 26.3% | 304 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 33.7% | 303 aa | Compounds | References |
Zea mays | Casein kinase II alpha | 332 aa | 26.2% | 302 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 38.2% | 304 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 31.4% | 296 aa | Compounds | References |