Detailed view for TVAG_441070

Basic information

TDR Targets ID: 887004
Trichomonas vaginalis, STE family protein kinase
Source Database / ID: 

pI: 6.9364 | Length (AA): 862 | MW (Da): 96591 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005488   binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131527)

Species Accession Gene Product
Arabidopsis thaliana AT3G13530   MAP3K epsilon protein kinase 1
Arabidopsis thaliana AT3G07980   mitogen-activated protein kinase kinase kinase 6
Candida albicans CaO19.3545   potential protein kinase similar to A.nidulans gene (sepH) required for septation in cytokinesis
Candida albicans CaO19.11029   MAPKKK essential for late nuclear division
Dictyostelium discoideum DDB_G0276465   armadillo repeat-containing protein
Entamoeba histolytica EHI_063010   serine/threonine protein kinase, putative
Entamoeba histolytica EHI_009590   serine/threonine protein kinase, putative
Giardia lamblia GL50803_16834   Kinase, STE Dicty2
Oryza sativa 4337283   Os04g0660500
Schmidtea mediterranea mk4.003900.04   Casein kinase II subunit beta
Schmidtea mediterranea mk4.020131.00  
Schmidtea mediterranea mk4.000517.00   Mitogen-activated protein kinase kinase kinase 19
Trichomonas vaginalis TVAG_091160   STE family protein kinase
Trichomonas vaginalis TVAG_038280   STE family protein kinase
Trichomonas vaginalis TVAG_441070   STE family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 33.1% 160 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 26.1% 283 aa Compounds References
Patiria pectinifera Cdc2 300 aa 27.3% 286 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 28.9% 284 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 28.7% 289 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0081 0.5 0.5
0.0091 1 0.5
0.0033 0.5 0.5
0.0063 1 1
0.0007 0.5 0.5
0.0042 0.5 0.5
0.0018 0.5 0.5
0.0059 1 1
0.0069 0.3067 0.5
0.0066 0.3101 0.5
0.0027 1 0.5
0.0016 0.5 0.5
0.0067 0.5 0.5
0.0039 0.5 0.5
0.0036 0.5 0.5
0.0061 0.6883 0.5304
0.0026 0.5 0.5
0.0008 0.5 0.5
0.0029 0.5 0.5
0.0011 1 0.5
0.0092 1 0.5
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0039 0.9485 0.5
0.0098 0.3242 0.2373
0.0059 1 1
0.0062 0.6935 0.5
0.0059 1 1
0.0022 0.5 0.5
0.0063 0.7244 0
0.0064 0.3377 0.5
0.0056 1 0.5
0.0081 1 0.5
0.0088 0.4477 1
0.0032 0.5 0.5
0.0093 0.8828 0.5
0.0037 1 0.5
0.0032 0.5 0.5
0.0039 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0033 1 1
0.0012 0.5 0.5
0.0007 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_441070 (Trichomonas vaginalis), STE family protein kinase
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