Detailed view for TVAG_401850

Basic information

TDR Targets ID: 887378
Trichomonas vaginalis, NAD dependent epimerase/dehydratase, putative
Source Database / ID: 

pI: 6.9807 | Length (AA): 458 | MW (Da): 51835 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00908   dTDP-4-dehydrorhamnose 3,5-epimerase
PF01370   NAD dependent epimerase/dehydratase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008830   dTDP-4-dehydrorhamnose 3,5-epimerase activity  
GO:0050662   coenzyme binding  
GO:0003824   catalytic activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_135813)

Species Accession Gene Product
Arabidopsis thaliana AT1G63000   UDP-4-keto-6-deoxy-d-glucose-3,5-epimerase-4-reductase 1
Dictyostelium discoideum DDB_G0274991   hypothetical protein
Entamoeba histolytica EHI_152130   hypothetical protein, conserved
Oryza sativa 9267465   Os02g0678400
Trypanosoma cruzi TcCLB.510349.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.503925.40   hypothetical protein
Trichomonas vaginalis TVAG_401850   NAD dependent epimerase/dehydratase, putative
Trichomonas vaginalis TVAG_016600   NAD dependent epimerase/dehydratase, putative
Trichomonas vaginalis TVAG_463120   NAD dependent epimerase/dehydratase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_401850 (Trichomonas vaginalis), NAD dependent epimerase/dehydratase, putative
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