Detailed view for TVAG_387870

Basic information

TDR Targets ID: 890447
Trichomonas vaginalis, sphingomyelin synthetase, putative
Source Database / ID: 

pI: 7.0523 | Length (AA): 264 | MW (Da): 30156 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14360   PAP2 superfamily C-terminal

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132218)

Species Accession Gene Product
Brugia malayi Bm1_27910   Sphingomyelin synthase-related 1
Caenorhabditis elegans CELE_F53B1.2   Protein F53B1.2
Drosophila melanogaster Dmel_CG32380   CG32380 gene product from transcript CG32380-RA
Echinococcus granulosus EgrG_000223400   sphingomyelin synthase protein 1
Entamoeba histolytica EHI_092670   hypothetical membrane-spanning protein
Echinococcus multilocularis EmuJ_000223400   sphingomyelin synthase protein 1
Homo sapiens ENSG00000156671   sterile alpha motif domain containing 8
Loa Loa (eye worm) LOAG_04426   hypothetical protein
Mus musculus ENSMUSG00000021770   sterile alpha motif domain containing 8
Schistosoma japonicum Sjp_0099280   ko:K04714 ceramide cholinephosphotransferase [EC2.7.8.3], putative
Schistosoma japonicum Sjp_0099270   Sphingomyelin synthase-related protein 1, putative
Schistosoma mansoni Smp_150380   spingomyelin synthetase-related
Schmidtea mediterranea mk4.002996.01   Sphingomyelin synthase-related 1
Trichomonas vaginalis TVAG_387870   sphingomyelin synthetase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_387870 (Trichomonas vaginalis), sphingomyelin synthetase, putative
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