Detailed view for TVAG_372910

Basic information

TDR Targets ID: 891846
Trichomonas vaginalis, 1-phosphatidylinositol phosphodiesterase, putative
Source Database / ID: 

pI: 8.273 | Length (AA): 260 | MW (Da): 30563 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00388   Phosphatidylinositol-specific phospholipase C, X domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008081   phosphoric diester hydrolase activity  
GO:0006629   lipid metabolic process  

Metabolic Pathways

Inositol phosphate metabolism (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134271)

Species Accession Gene Product
Candida albicans CaO19.5797   one of two closely related genes similar to bacterial phosphatidylinositol-specific phospholipase C
Candida albicans CaO19.1586   one of two closely related genes similar to bacterial phosphatidylinositol-specific phospholipase C
Candida albicans CaO19.13219   one of two closely related genes similar to bacterial phosphatidylinositol-specific phospholipase C
Candida albicans CaO19.9159   one of two closely related genes similar to bacterial phosphatidylinositol-specific phospholipase C
Trichomonas vaginalis TVAG_301070   1-phosphatidylinositol phosphodiesterase, putative
Trichomonas vaginalis TVAG_372910   1-phosphatidylinositol phosphodiesterase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_372910 (Trichomonas vaginalis), 1-phosphatidylinositol phosphodiesterase, putative
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