pI: 10.2285 |
Length (AA): 91 |
MW (Da): 10564 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129239)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G22425 | putative signal peptidase complex subunit 1 |
Arabidopsis thaliana | AT4G40042 | signal peptidase subunit-12 |
Brugia malayi | Bm1_18865 | microsomal signal peptidase 12 kDa subunit |
Caenorhabditis elegans | CELE_C34B2.10 | Protein C34B2.10 |
Dictyostelium discoideum | DDB_G0278371 | microsomal signal peptidase subunit |
Drosophila melanogaster | Dmel_CG11500 | Spase 12-subunit |
Echinococcus granulosus | EgrG_000819800 | signal peptidase complex subunit 1 |
Entamoeba histolytica | EHI_200720 | signal peptidase complex subunit, putative |
Entamoeba histolytica | EHI_193470 | signal peptidase complex subunit, putative |
Echinococcus multilocularis | EmuJ_000819800 | signal peptidase complex subunit 1 |
Giardia lamblia | GL50803_3154 | Hypothetical protein |
Homo sapiens | ENSG00000114902 | signal peptidase complex subunit 1 homolog (S. cerevisiae) |
Mus musculus | ENSMUSG00000021917 | signal peptidase complex subunit 1 homolog (S. cerevisiae) |
Neospora caninum | NCLIV_004530 | microsomal signal peptidase subunit SPCS1 domain- containing protein, putative |
Oryza sativa | 4352133 | Os12g0438900 |
Onchocerca volvulus | OVOC1702 | Putative signal peptidase complex subunit 1 |
Plasmodium berghei | PBANKA_1011300 | signal peptidase complex subunit SPC1, putative |
Plasmodium falciparum | PF3D7_1433600 | signal peptidase complex subunit SPC1, putative |
Plasmodium knowlesi | PKNH_0420200 | signal peptidase complex subunit SPC1, putative |
Plasmodium vivax | PVX_084850 | microsomal signal peptidase 12 kDa subunit, putative |
Plasmodium yoelii | PY06001 | signal peptidase 12kDa subunit |
Saccharomyces cerevisiae | YJR010C-A | Spc1p |
Schistosoma japonicum | Sjp_0016650 | IPR009542,Microsomal signal peptidase 12 kDa subunit,domain-containing |
Schistosoma mansoni | Smp_004820 | hypothetical protein |
Toxoplasma gondii | TGME49_321400 | microsomal signal peptidase (spc12) domain-containing protein |
Trichomonas vaginalis | TVAG_177430 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C34B2.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C34B2.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C34B2.10 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C34B2.10 | Caenorhabditis elegans | sterile | wormbase |
TGME49_321400 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.