Detailed view for TVAG_035040

Basic information

TDR Targets ID: 892599
Trichomonas vaginalis, hypothetical protein
Source Database / ID: 

pI: 5.6514 | Length (AA): 1505 | MW (Da): 167727 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00635   MSP (Major sperm protein) domain
PF15780   Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130978)

Species Accession Gene Product
Homo sapiens ENSG00000181378   coiled-coil domain containing 108
Leishmania braziliensis LbrM.35.3100   hypothetical protein, conserved
Leishmania donovani LdBPK_363030.1   hypothetical protein, conserved
Leishmania infantum LinJ.36.3030   hypothetical protein, conserved
Leishmania major LmjF.36.2880   hypothetical protein, conserved
Leishmania mexicana LmxM.36.2880   hypothetical protein, conserved
Mus musculus ENSMUSG00000047021   coiled-coil domain containing 108
Neospora caninum NCLIV_004800   hypothetical protein, conserved
Plasmodium yoelii PY03228   hypothetical protein
Plasmodium yoelii PY03230   hypothetical protein
Schistosoma japonicum Sjp_0046660   Coiled-coil domain-containing protein 108, putative
Schistosoma japonicum Sjp_0084680   Coiled-coil domain-containing protein 108, putative
Schistosoma japonicum Sjp_0046670   hypothetical protein
Schistosoma japonicum Sjp_0114300   hypothetical protein
Schistosoma mansoni Smp_163070   hypothetical protein
Trypanosoma brucei gambiense Tbg972.10.9020   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.7350   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_6330   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507681.130   hypothetical protein, conserved
Toxoplasma gondii TGME49_221220   hypothetical protein
Trichomonas vaginalis TVAG_035040   hypothetical protein

Essentiality

TVAG_035040 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.7350 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.7350 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.7350 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.7350 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_221220 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_035040 (Trichomonas vaginalis), hypothetical protein
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