Detailed view for TVAG_125560

Basic information

TDR Targets ID: 893072
Trichomonas vaginalis, CMGC family protein kinase
Source Database / ID: 

pI: 8.8701 | Length (AA): 320 | MW (Da): 36474 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_143898)

Species Accession Gene Product
Leishmania braziliensis LbrM.02.0390   casein kinase II, alpha chain, putative
Leishmania donovani LdBPK_020330.1   casein kinase II, alpha chain, putative
Leishmania infantum LinJ.02.0330   casein kinase II, alpha chain, putative
Leishmania major LmjF.02.0360   casein kinase II, alpha chain, putative
Leishmania mexicana LmxM.02.0360   casein kinase II, alpha chain, putative
Trypanosoma brucei gambiense Tbg.972.2.980   casein kinase II, alpha chain
Trypanosoma brucei Tb927.2.2430   casein kinase II, alpha chain
Trypanosoma congolense TcIL3000_2_220   casein kinase II, alpha chain
Trypanosoma cruzi TcCLB.503513.10   casein kinase II, alpha chain, putative
Trypanosoma cruzi TcCLB.508741.320   casein kinase II, alpha chain, putative
Trichomonas vaginalis TVAG_125560   CMGC family protein kinase
Trichomonas vaginalis TVAG_044300   CMGC family protein kinase

Essentiality

TVAG_125560 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.2430 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.2430 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.2430 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.2.2430 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 28.0% 321 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.8% 309 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 27.3% 311 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 32.5% 166 aa Compounds References
Patiria pectinifera Cdc2 300 aa 27.8% 306 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0026 0.5 0.5
0.0066 0.3101 0.5
0.0004 0.5 0.5
0.0092 1 0.5
0.0018 0.5 0.5
0.0016 0.5 0.5
0.0037 1 0.5
0.0023 0.5 0.5
0.0088 0.4477 1
0.0042 0.5 0.5
0.0007 0.5 0.5
0.0029 0.5 0.5
0.0069 0.3067 0.5
0.0007 0.5 0.5
0.0061 0.6883 0.5304
0.0062 0.6935 0.5
0.0036 0.5 0.5
0.0067 0.5 0.5
0.0059 1 1
0.0008 0.5 0.5
0.0007 0.5 0.5
0.0003 0.5 0.5
0.0011 1 0.5
0.0012 0.5 0.5
0.0081 0.5 0.5
0.0033 0.5 0.5
0.0063 1 1
0.0093 0.8828 0.5
0.0039 0.5 0.5
0.0027 1 0.5
0.0012 0.5 0.5
0.0032 0.5 0.5
0.0059 1 1
0.0039 0.9485 0.5
0.0039 0.5 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.2373
0.0032 0.5 0.5
0.0016 0.5 0.5
0.0059 1 1
0.0056 1 0.5
0.0063 0.7244 0
0.0091 1 0.5
0.0022 0.5 0.5
0.0081 1 0.5
0.0064 0.3377 0.5
0.0033 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_125560 (Trichomonas vaginalis), CMGC family protein kinase
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