Detailed view for TVAG_337250

Basic information

TDR Targets ID: 893826
Trichomonas vaginalis, HIV-1 rev binding protein, hrbl, putative
Source Database / ID: 

pI: 9.4851 | Length (AA): 445 | MW (Da): 46679 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01412   Putative GTPase activating protein for Arf

Gene Ontology

Mouse over links to read term descriptions.
GO:0005096   GTPase activator activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130835)

Species Accession Gene Product
Cryptosporidium parvum cgd5_140   ARF GTPase activating protein, putative
Dictyostelium discoideum DDB_G0267538   Arf GTPase activating protein
Entamoeba histolytica EHI_095050   hypothetical protein, conserved
Giardia lamblia GL50803_2834   ARF GAP
Homo sapiens ENSG00000106351   ArfGAP with FG repeats 2
Leishmania braziliensis LbrM.35.3370   ADP-ribosylation factor GTPase activating protein, putative
Leishmania donovani LdBPK_363300.1   ADP-ribosylation factor GTPase activating protein, putative
Leishmania infantum LinJ.36.3300   ADP-ribosylation factor GTPase activating protein, putative
Leishmania major LmjF.36.3150   ADP-ribosylation factor GTPase activating protein, putative
Leishmania mexicana LmxM.36.3150   ADP-ribosylation factor GTPase activating protein, putative
Loa Loa (eye worm) LOAG_12218   hypothetical protein
Mus musculus ENSMUSG00000029722   ArfGAP with FG repeats 2
Oryza sativa 4332692   Os03g0323500
Trypanosoma brucei gambiense Tbg972.11.10630   ADP-ribosylation factor GTPase activating protein, putative
Trypanosoma brucei Tb927.11.9470   ADP-ribosylation factor GTPase activating protein, putative
Trypanosoma congolense TcIL3000.11.9940   ADP-ribosylation factor GTPase activating protein, putative
Trypanosoma cruzi TcCLB.508851.120   ADP-ribosylation factor GTPase activating protein, putative
Trypanosoma cruzi TcCLB.511589.70   ADP-ribosylation factor GTPase activating protein, putative
Trichomonas vaginalis TVAG_337250   HIV-1 rev binding protein, hrbl, putative

Essentiality

TVAG_337250 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.1230 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.1230 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.1230 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.01.1230 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_337250 (Trichomonas vaginalis), HIV-1 rev binding protein, hrbl, putative
Title for this comment
Comment