Detailed view for TVAG_403270

Basic information

TDR Targets ID: 901263
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 9.4985 | Length (AA): 217 | MW (Da): 24663 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05832   Eukaryotic protein of unknown function (DUF846)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127609)

Species Accession Gene Product
Arabidopsis thaliana AT1G09330   protein ECHIDNA
Brugia malayi Bm1_46935   FAM18-like protein CG5021
Candida albicans CaO19.4862   C terminal eukaryotic DUF846
Candida albicans CaO19.12326   C terminal eukaryotic DUF846
Caenorhabditis elegans CELE_C34D4.4   Protein C34D4.4, isoform B
Cryptosporidium hominis Chro.20094   FAM18-like protein
Cryptosporidium parvum cgd2_830   conserved protein with 4x transmembrane domains
Dictyostelium discoideum DDB_G0276319   hypothetical protein
Dictyostelium discoideum DDB_G0286703   hypothetical protein
Drosophila melanogaster Dmel_CG5021   CG5021 gene product from transcript CG5021-RC
Echinococcus granulosus EgrG_001126500   protein FAM18A
Entamoeba histolytica EHI_148020   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_001126500   protein FAM18A
Giardia lamblia GL50803_12035   Hypothetical protein
Homo sapiens ENSG00000175106   trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)
Homo sapiens ENSG00000166676   trans-golgi network vesicle protein 23 homolog A (S. cerevisiae)
Homo sapiens ENSG00000171928   trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
Leishmania braziliensis LbrM.27.2050   hypothetical protein, conserved
Leishmania donovani LdBPK_271810.1   Eukaryotic protein of unknown function (DUF846), putative
Leishmania infantum LinJ.27.1810   hypothetical protein, conserved
Leishmania major LmjF.27.1900   hypothetical protein, conserved
Leishmania mexicana LmxM.27.1900   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_00530   hypothetical protein
Mus musculus ENSMUSG00000014177   trans-golgi network vesicle protein 23B
Mus musculus ensembl-mmu:ENSMUSG00000050908   trans-golgi network vesicle protein 23A
Neospora caninum NCLIV_005220   hypothetical protein, conserved
Oryza sativa 4337877   Os05g0159100
Oryza sativa 4326837   Os01g0331900
Plasmodium berghei PBANKA_1322600   golgi apparatus membrane protein TVP23, putative
Plasmodium falciparum PF3D7_1458900   golgi apparatus membrane protein TVP23, putative
Plasmodium knowlesi PKNH_1222900   golgi apparatus membrane protein TVP23, putative
Plasmodium vivax PVX_117515   golgi apparatus membrane protein TVP23, putative
Plasmodium yoelii PY04684   hypothetical protein
Plasmodium yoelii PY04685   hypothetical protein
Saccharomyces cerevisiae YDR084C   Tvp23p
Schistosoma japonicum Sjp_0304930   Protein FAM18A, putative
Schistosoma mansoni Smp_056850   hypothetical protein
Schmidtea mediterranea mk4.000071.00   Uncharacterized Golgi apparatus membrane protein-like protein
Trypanosoma brucei gambiense Tbg.972.2.2480   hypothetical protein, conserved
Trypanosoma brucei Tb927.2.4410   Eukaryotic protein of unknown function (DUF846), putative
Trypanosoma congolense TcIL3000_0_51430   Eukaryotic protein of unknown function (DUF846), putative
Trypanosoma congolense TcIL3000_2_810   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509099.89   Eukaryotic protein of unknown function (DUF846), putative
Trypanosoma cruzi TcCLB.509319.40   Eukaryotic protein of unknown function (DUF846), putative
Toxoplasma gondii TGME49_221700   hypothetical protein
Trichomonas vaginalis TVAG_403270   conserved hypothetical protein

Essentiality

TVAG_403270 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.2.4410 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.4410 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.4410 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.2.4410 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_221700 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_403270 (Trichomonas vaginalis), conserved hypothetical protein
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