pI: 10.6734 |
Length (AA): 139 |
MW (Da): 15933 |
Paralog Number:
6
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127262)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G22230 | 60S ribosomal protein L27-2 |
Arabidopsis thaliana | AT4G15000 | 60S ribosomal protein L27-3 |
Arabidopsis thaliana | AT2G32220 | 60S ribosomal protein L27-1 |
Babesia bovis | BBOV_III010680 | ribosomal L27e protein family protein |
Brugia malayi | Bm1_28975 | 60S ribosomal protein L27 |
Caenorhabditis elegans | CELE_C53H9.1 | Protein RPL-27 |
Cryptosporidium hominis | Chro.10333 | ribosomal protein L27 |
Cryptosporidium parvum | cgd1_3000 | 60S ribosomal protein L27 |
Dictyostelium discoideum | DDB_G0271298 | S60 ribosomal protein L27 |
Drosophila melanogaster | Dmel_CG4759 | Ribosomal protein L27 |
Echinococcus granulosus | EgrG_000724800 | 60S ribosomal protein L27 |
Entamoeba histolytica | EHI_183480 | 60S ribosomal protein L27, putative |
Entamoeba histolytica | EHI_146370 | 60S ribosomal protein L27, putative |
Echinococcus multilocularis | EmuJ_000724800 | 60S ribosomal protein L27 |
Giardia lamblia | GL50803_8462 | Ribosomal protein L27 |
Homo sapiens | ENSG00000131469 | ribosomal protein L27 |
Leishmania braziliensis | LbrM.32.2930 | ribosomal protein L27, putative |
Leishmania braziliensis | LbrM.32.2950 | ribosomal protein L27, putative |
Leishmania donovani | LdBPK_322850.1 | ribosomal protein L27, putative |
Leishmania donovani | LdBPK_322830.1 | ribosomal protein L27, putative |
Leishmania infantum | LinJ.32.2850 | ribosomal protein L27, putative |
Leishmania infantum | LinJ.32.2830 | ribosomal protein L27, putative |
Leishmania major | LmjF.32.2690 | ribosomal protein L27, putative |
Leishmania major | LmjF.32.2710 | ribosomal protein L27, putative |
Leishmania mexicana | LmxM.31.2690 | ribosomal protein L27, putative |
Loa Loa (eye worm) | LOAG_08058 | ribosomal protein L27 |
Mus musculus | ENSMUSG00000063316 | ribosomal protein L27 |
Neospora caninum | NCLIV_025160 | hypothetical protein |
Oryza sativa | 4329034 | Os02g0284600 |
Oryza sativa | 4349409 | Os10g0564300 |
Onchocerca volvulus | OVOC13421 |
|
Plasmodium berghei | PBANKA_1324400 | 60S ribosomal protein L27, putative |
Plasmodium falciparum | PF3D7_1460700 | 60S ribosomal protein L27 |
Plasmodium knowlesi | PKNH_1221000 | 60S ribosomal protein L27, putative |
Plasmodium vivax | PVX_117420 | 60S ribosomal protein L27, putative |
Plasmodium yoelii | PY01750 | 60S ribosomal protein L27 homolog |
Saccharomyces cerevisiae | YHR010W | ribosomal 60S subunit protein L27A |
Saccharomyces cerevisiae | YDR471W | ribosomal 60S subunit protein L27B |
Schistosoma japonicum | Sjp_0011460 | ko:K02901 large subunit ribosomal protein L27e, putative |
Schistosoma mansoni | Smp_063350 | 60S ribosomal protein L27e |
Schmidtea mediterranea | mk4.002567.08 | 60S ribosomal protein L27 |
Schmidtea mediterranea | mk4.001433.00 | 60S ribosomal protein L27 |
Trypanosoma brucei gambiense | Tbg972.11.17830 | 60S ribosomal protein L27, putative |
Trypanosoma brucei gambiense | Tbg972.11.17810 | 60S ribosomal protein L27, putative |
Trypanosoma brucei | Tb927.11.15900 | 60S ribosomal protein L27, putative |
Trypanosoma brucei | Tb927.11.15880 | 60S ribosomal protein L27, putative |
Trypanosoma cruzi | TcCLB.511545.20 | ribosomal protein L27, putative |
Trypanosoma cruzi | TcCLB.511545.40 | ribosomal protein L27, putative |
Trypanosoma cruzi | TcCLB.506817.30 | ribosomal protein L27, putative |
Trypanosoma cruzi | TcCLB.506817.50 | ribosomal protein L27, putative |
Toxoplasma gondii | TGME49_262690 | ribosomal protein RPL27 |
Theileria parva | TP02_0078 | 60S ribosomal protein L27e, putative |
Trichomonas vaginalis | TVAG_302830 | 60S ribosomal protein L27e, putative |
Trichomonas vaginalis | TVAG_189070 | 60S ribosomal protein L27e, putative |
Trichomonas vaginalis | TVAG_380870 | 60S ribosomal protein L27e, putative |
Trichomonas vaginalis | TVAG_306310 | 60S ribosomal protein L27e, putative |
Trichomonas vaginalis | TVAG_337950 | 60S ribosomal protein L27e, putative |
Trichomonas vaginalis | TVAG_140290 | 60S ribosomal protein L27e, putative |
Trichomonas vaginalis | TVAG_215980 | 60S ribosomal protein L27e, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.7535 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.7535 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.7535 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.7535 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C53H9.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C53H9.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C53H9.1 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_262690 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.