Detailed view for PF3D7_0724200

Basic information

TDR Targets ID: 902
Plasmodium falciparum, type 2A phosphatase-associated protein 42, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.2675 | Length (AA): 427 | MW (Da): 51569 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04177   TAP42-like family

Gene Ontology

Mouse over links to read term descriptions.
GO:0009966   regulation of signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
40 255 4iyp (A) 24 221 25.00 0 1 0.645755 -0.02
57 243 2v0p (B) 40 220 30.00 0.0018 1 0.554739 0.26
193 410 4tql (A) 9 234 11.00 0.0024 0.02 0.654739 -0.99

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, Ring, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile early trophozoite, Sporozoite. PlasmoDB Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_128317)

Species Accession Gene Product
Arabidopsis thaliana AT5G53000   PP2A regulatory subunit TAP46
Babesia bovis BBOV_IV000930   hypothetical protein
Brugia malayi Bm1_06780   TAP42-like family protein
Candida albicans CaO19.12096   TOR signal transduction pathway
Candida albicans CaO19.4626   TOR signal transduction pathway
Caenorhabditis elegans CELE_Y71H2B.3   Protein PPFR-4
Cryptosporidium hominis Chro.40163   hypothetical protein
Cryptosporidium parvum cgd4_1430   hypothetical protein
Dictyostelium discoideum DDB_G0279647   hypothetical protein
Drosophila melanogaster Dmel_CG31852   Two A-associated protein of 42kDa
Echinococcus granulosus EgrG_000163000   immunoglobulin binding protein 1
Entamoeba histolytica EHI_000740   hypothetical protein
Echinococcus multilocularis EmuJ_000163000   immunoglobulin binding protein 1
Homo sapiens ENSG00000089289   immunoglobulin (CD79A) binding protein 1
Loa Loa (eye worm) LOAG_05381   hypothetical protein
Mus musculus ENSMUSG00000046717   immunoglobulin (CD79A) binding protein 1b
Mus musculus ensembl-mmu:ENSMUSG00000031221   immunoglobulin (CD79A) binding protein 1
Neospora caninum NCLIV_061980   hypothetical protein
Neospora caninum NCLIV_061970   hypothetical protein
Oryza sativa 4349739   Os11g0141000
Oryza sativa 4351453   Os12g0137500
Plasmodium berghei PBANKA_0621700   type 2A phosphatase-associated protein 42, putative
Plasmodium falciparum PF3D7_0724200   type 2A phosphatase-associated protein 42, putative
Plasmodium knowlesi PKNH_0319600   type 2A phosphatase-associated protein 42, putative
Plasmodium vivax PVX_096135   type 2A phosphatase-associated protein 42, putative
Plasmodium yoelii PY01610   immunoglobulin-binding protein 1
Saccharomyces cerevisiae YMR028W   Tap42p
Schistosoma japonicum Sjp_0079580   Immunoglobulin-binding protein 1, putative
Schistosoma mansoni Smp_154230.1   hypothetical protein
Schistosoma mansoni Smp_154230.2   hypothetical protein
Schmidtea mediterranea mk4.001522.04   Immunoglobulin-binding protein 1
Toxoplasma gondii TGME49_218250   TAP42 family protein
Theileria parva TP01_0115   hypothetical protein
Trichomonas vaginalis TVAG_296230   conserved hypothetical protein

Essentiality

PF3D7_0724200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y71H2B.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y71H2B.3 Caenorhabditis elegans larval arrest wormbase
CELE_Y71H2B.3 Caenorhabditis elegans larval lethal wormbase
CELE_Y71H2B.3 Caenorhabditis elegans sterile wormbase
YMR028W Saccharomyces cerevisiae inviable yeastgenome
TGME49_218250 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Pkno005211AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pkno005211; Recombinant protein: full-length; Source: P knowlesi; hypothetical protein homolog ; Identifier: PKH_031790

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_0724200 (Plasmodium falciparum), type 2A phosphatase-associated protein 42, putative
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