pI: 8.0882 |
Length (AA): 754 |
MW (Da): 83915 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127280)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G18550 | ATP binding microtubule motor family protein |
Arabidopsis thaliana | AT3G49650 | P-loop containing nucleoside triphosphate hydrolase-like protein |
Babesia bovis | BBOV_IV003380 | kinesin, putative |
Candida albicans | CaO19.7353 | kinesin motor domain protein |
Cryptosporidium hominis | Chro.30351 | similar to protein FLJ37300 |
Cryptosporidium parvum | cgd3_3090 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0293198 | kinesin family member 10 |
Drosophila melanogaster | Dmel_CG9913 | Kinesin family member 19A ortholog |
Drosophila melanogaster | Dmel_CG10923 | Kinesin-like protein at 67A |
Giardia lamblia | GL50803_4371 | Kinesin-8 |
Homo sapiens | ENSG00000186185 | kinesin family member 18B |
Homo sapiens | ENSG00000121621 | kinesin family member 18A |
Homo sapiens | ENSG00000196169 | kinesin family member 19 |
Mus musculus | ENSMUSG00000010021 | kinesin family member 19A |
Mus musculus | 101055939 | kinesin-like protein KIF19-like |
Mus musculus | ENSMUSG00000027115 | kinesin family member 18A |
Mus musculus | ENSMUSG00000051378 | kinesin family member 18B |
Neospora caninum | NCLIV_007650 | hypothetical protein |
Neospora caninum | NCLIV_065120 | kinesin motor domain-containing protein, putative |
Oryza sativa | 4334272 | Os03g0773600 |
Oryza sativa | 4324211 | Os01g0605500 |
Plasmodium berghei | PBANKA_0202700 | kinesin-8, putative |
Plasmodium berghei | PBANKA_0805900 | kinesin-8, putative |
Plasmodium falciparum | PF3D7_0319400 | kinesin-8, putative |
Plasmodium falciparum | PF3D7_0111000 | kinesin-8, putative |
Plasmodium knowlesi | PKNH_0202500 | kinesin-8, putative |
Plasmodium knowlesi | PKNH_0821800 | kinesin-8, putative |
Plasmodium vivax | PVX_081250 | kinesin-8, putative |
Plasmodium vivax | PVX_095265 | kinesin-8, putative |
Plasmodium yoelii | PY00972 | kinesin-related protein |
Plasmodium yoelii | PY02372 | kinesin-like protein-related |
Saccharomyces cerevisiae | YGL216W | tubulin-dependent ATPase KIP3 |
Schmidtea mediterranea | mk4.008703.00 | |
Toxoplasma gondii | TGME49_253110 | kinesin motor domain-containing protein |
Toxoplasma gondii | TGME49_249020 | kinesin motor domain-containing protein |
Theileria parva | TP01_1097 | kinesin, putative |
Trichomonas vaginalis | TVAG_447880 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_395330 | kinesin eg-5, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_0202700 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_0805900 | Plasmodium berghei | Dispensable | plasmo |
TGME49_253110 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_249020 | Toxoplasma gondii | Probably non-essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.