pI: 6.9487 |
Length (AA): 355 |
MW (Da): 40175 |
Paralog Number:
10
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127803)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G36050 | Endoplasmic reticulum vesicle transporter protein |
Arabidopsis thaliana | AT1G22200 | Endoplasmic reticulum vesicle transporter protein |
Brugia malayi | Bm1_33800 | Serologically defined breast cancer antigen NY-BR-84 homolog |
Candida albicans | CaO19.8218 | ER-Golgi transport vesicle protein |
Candida albicans | CaO19.586 | ER-Golgi transport vesicle protein |
Caenorhabditis elegans | CELE_K09E9.2 | Protein ERV-46 |
Cryptosporidium hominis | Chro.70352 | serologically defined breast cancer antigen 84 |
Cryptosporidium parvum | cgd7_3130 | ER vesicle protein; Erv41p, transmembrane region near C terminus and possible N region transmembrane |
Dictyostelium discoideum | DDB_G0292002 | endoplasmic reticulum-golgi intermediate compartment protein 3 |
Drosophila melanogaster | Dmel_CG7011 | CG7011 gene product from transcript CG7011-RA |
Echinococcus granulosus | EgrG_001055100 | endoplasmic reticulum Golgi intermediate |
Entamoeba histolytica | EHI_079180 | hypothetical protein, conserved |
Entamoeba histolytica | EHI_182970 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_001055100 | endoplasmic reticulum Golgi intermediate |
Homo sapiens | ENSG00000125991 | ERGIC and golgi 3 |
Leishmania braziliensis | LbrM.31.3090 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_312830.1 | Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative |
Leishmania infantum | LinJ.31.2830 | hypothetical protein, conserved |
Leishmania major | LmjF.31.2740 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.30.2740 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05019 | hypothetical protein |
Mus musculus | ENSMUSG00000005881 | ERGIC and golgi 3 |
Oryza sativa | 4336024 | Os04g0455900 |
Oryza sativa | 4339163 | Os05g0490200 |
Saccharomyces cerevisiae | YAL042W | Erv46p |
Schistosoma japonicum | Sjp_0019110 | Endoplasmic reticulum-Golgi intermediate compartment protein 3, putative |
Schistosoma mansoni | Smp_040360 | serologically defined breast cancer antigen ny-br-84-related |
Schmidtea mediterranea | mk4.012488.00 | Endoplasmic reticulum-Golgi intermediate compartment protein 3 |
Schmidtea mediterranea | mk4.007664.00 | |
Trypanosoma brucei gambiense | Tbg972.4.5290 | hypothetical protein, conserved |
Trypanosoma brucei gambiense | Tbg972.8.7570 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.8.7270 | Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative |
Trypanosoma brucei | Tb927.4.5100 | Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative |
Trypanosoma congolense | TcIL3000_0_00550 | Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative |
Trypanosoma congolense | TcIL3000_8_7410 | Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative |
Trypanosoma cruzi | TcCLB.510593.30 | Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative |
Trichomonas vaginalis | TVAG_172950 | Endoplasmic reticulum-golgi intermediate compartment protein, putative |
Trichomonas vaginalis | TVAG_396530 | Endoplasmic reticulum-golgi intermediate compartment protein, putative |
Trichomonas vaginalis | TVAG_442240 | er-golgi intermediate compartment 32 kD protein, putative |
Trichomonas vaginalis | TVAG_317730 | Endoplasmic reticulum-golgi intermediate compartment protein, putative |
Trichomonas vaginalis | TVAG_100310 | ptx1 protein, putative |
Trichomonas vaginalis | TVAG_177510 | er-golgi intermediate compartment 32 kD protein, putative |
Trichomonas vaginalis | TVAG_470170 | Endoplasmic reticulum-golgi intermediate compartment protein, putative |
Trichomonas vaginalis | TVAG_394520 | Endoplasmic reticulum-golgi intermediate compartment protein, putative |
Trichomonas vaginalis | TVAG_036780 | Endoplasmic reticulum-golgi intermediate compartment protein, putative |
Trichomonas vaginalis | TVAG_342940 | Endoplasmic reticulum-golgi intermediate compartment protein, putative |
Trichomonas vaginalis | TVAG_469210 | ptx1 protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.7270 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.7270 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.7270 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.8.7270 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.4.5100 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.5100 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.5100 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.5100 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.