Detailed view for TVAG_355010

Basic information

TDR Targets ID: 903834
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 5.0223 | Length (AA): 358 | MW (Da): 41038 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127069)

Species Accession Gene Product
Arabidopsis thaliana AT5G14170   chromodomain remodeling complex protein CHC1
Arabidopsis thaliana AT3G01890   Swi/Snf complex component SWP73-like protein
Brugia malayi Bm1_44510   brahma associated protein 60 kDa
Brugia malayi Bm1_38005   Amiloride-sensitive sodium channel family protein
Brugia malayi Bm1_55005   brahma associated protein 60 kDa
Candida albicans CaO19.9805   subunit of SWI/SNF transcription activation complex
Candida albicans CaO19.2265   subunit of SWI/SNF transcription activation complex
Caenorhabditis elegans CELE_T28F2.7   Protein ACD-5
Caenorhabditis elegans CELE_C18E3.2   Protein SWSN-2.2
Caenorhabditis elegans CELE_ZK1128.5   Protein HAM-3
Cryptosporidium hominis Chro.30113   SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d3; Rsc6p
Cryptosporidium parvum cgd3_840   RSC6/BAF60A ortholog with a SWIB domain
Dictyostelium discoideum DDB_G0273203   CHC group protein
Dictyostelium discoideum DDB_G0273725   CHC group protein
Drosophila melanogaster Dmel_CG10972   pickpocket 12
Drosophila melanogaster Dmel_CG4303   Brahma associated protein 60kD
Drosophila melanogaster Dmel_CG3478   pickpocket
Echinococcus granulosus EgrG_000613400   SWI:SNF matrix associated
Echinococcus multilocularis EmuJ_000612800   SWI:SNF matrix associated
Echinococcus multilocularis EmuJ_000613200   SWI:SNF matrix associated
Echinococcus multilocularis EmuJ_000613400   SWI:SNF matrix associated
Homo sapiens ENSG00000108684   acid-sensing (proton-gated) ion channel 2
Homo sapiens ENSG00000082014   SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Homo sapiens ENSG00000110881   acid-sensing (proton-gated) ion channel 1
Homo sapiens ENSG00000066117   SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Homo sapiens ENSG00000108604   SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
Loa Loa (eye worm) LOAG_02020   brahma associated protein
Loa Loa (eye worm) LOAG_03801   amiloride-sensitive sodium channel family protein
Mus musculus ENSMUSG00000028949   SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Mus musculus ENSMUSG00000023018   SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Mus musculus ENSMUSG00000020704   acid-sensing (proton-gated) ion channel 2
Mus musculus ENSMUSG00000078619   SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
Mus musculus ENSMUSG00000023017   acid-sensing (proton-gated) ion channel 1
Oryza sativa 4335638   Os04g0382100
Onchocerca volvulus OVOC4277  
Saccharomyces cerevisiae YNR023W   Snf12p
Saccharomyces cerevisiae YCR052W   Rsc6p
Schistosoma japonicum Sjp_0015370   SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2, putative
Schistosoma japonicum Sjp_0119920   SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1, putative
Schistosoma mansoni Smp_134310   brg-1 associated factor
Schmidtea mediterranea mk4.000918.00   Brahma-associated protein of 60 kDa
Trichomonas vaginalis TVAG_355010   conserved hypothetical protein

Essentiality

TVAG_355010 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C18E3.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C18E3.2 Caenorhabditis elegans larval arrest wormbase
CELE_ZK1128.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK1128.5 Caenorhabditis elegans larval arrest wormbase
CELE_ZK1128.5 Caenorhabditis elegans larval lethal wormbase
CELE_ZK1128.5 Caenorhabditis elegans slow growth wormbase
CELE_ZK1128.5 Caenorhabditis elegans sterile wormbase
YCR052W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens acid-sensing (proton-gated) ion channel 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_355010 (Trichomonas vaginalis), conserved hypothetical protein
Title for this comment
Comment