pI: 4.7482 |
Length (AA): 199 |
MW (Da): 22015 |
Paralog Number:
15
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_132710)
Species | Accession | Gene Product |
---|---|---|
Candida albicans | CaO19.8060 | one of two genes similar to S. cerevisiae VPT52 (YKR014C) rab5-like GTPase involved in vacuolar protein sorting and endocytosis |
Candida albicans | CaO19.430 | one of two genes similar to S. cerevisiae VPT52 (YKR014C) rab5-like GTPase involved in vacuolar protein sorting and endocytosis |
Dictyostelium discoideum | DDB_G0277441 | Rab GTPase |
Drosophila melanogaster | Dmel_CG3870 | CG3870 gene product from transcript CG3870-RA |
Neospora caninum | NCLIV_060890 | Ras family domain-containing protein, putative |
Saccharomyces cerevisiae | YNL093W | Rab family GTPase YPT53 |
Schmidtea mediterranea | mk4.002539.03 | |
Toxoplasma gondii | TGME49_219720 | Ras-related protein Rab-5C, putative |
Trichomonas vaginalis | TVAG_531820 | Rab17, putative |
Trichomonas vaginalis | TVAG_019470 | RAB, putative |
Trichomonas vaginalis | TVAG_024790 | septum-promoting GTP-binding protein, putative |
Trichomonas vaginalis | TVAG_179640 | Rab21, putative |
Trichomonas vaginalis | TVAG_453170 | GTP-binding protein ypt11, putative |
Trichomonas vaginalis | TVAG_020610 | RAB-18, putative |
Trichomonas vaginalis | TVAG_349870 | Rabx15 protein, putative |
Trichomonas vaginalis | TVAG_328110 | RAB-18, putative |
Trichomonas vaginalis | TVAG_474500 | Rabx26 protein, putative |
Trichomonas vaginalis | TVAG_090060 | GTP-binding protein Rab2, putative |
Trichomonas vaginalis | TVAG_074410 | Rabx41 protein, putative |
Trichomonas vaginalis | TVAG_211200 | Rabx21 protein, putative |
Trichomonas vaginalis | TVAG_257310 | Rab21, putative |
Trichomonas vaginalis | TVAG_116360 | Rab17, putative |
Trichomonas vaginalis | TVAG_317250 | Rabx2a protein, putative |
Trichomonas vaginalis | TVAG_391920 | Rab7g protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_219720 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.