pI: 5.2085 |
Length (AA): 298 |
MW (Da): 33091 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127230)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G62500 | microtubule-associated protein, RP/EB family member 1B |
Arabidopsis thaliana | AT5G67270 | microtubule-associated protein RP/EB family member 1C |
Arabidopsis thaliana | AT3G47690 | microtubule end binding protein EB1A |
Babesia bovis | BBOV_III000990 | microtubule-associated protein RP/EB family member protein |
Brugia malayi | Bm1_50270 | EBF3-S |
Candida albicans | CaO19.8293 | probable microtubule-binding protein similar to S. cerevisiae BIM1 (YER016W) |
Candida albicans | CaO19.676 | probable microtubule-binding protein similar to S. cerevisiae BIM1 (YER016W) |
Caenorhabditis elegans | CELE_Y59A8B.9 | Protein EBP-3 |
Caenorhabditis elegans | CELE_Y59A8B.7 | Protein EBP-1 |
Cryptosporidium hominis | Chro.70271 | microtubule-associated protein |
Cryptosporidium parvum | cgd7_2370 | EB1 like microtubule binding protein |
Dictyostelium discoideum | DDB_G0283607 | microtubule-associated protein EB1 |
Drosophila melanogaster | Dmel_CG3265 | CG3265 gene product from transcript CG3265-RF |
Drosophila melanogaster | Dmel_CG32371 | CG32371 gene product from transcript CG32371-RA |
Drosophila melanogaster | Dmel_CG18190 | CG18190 gene product from transcript CG18190-RB |
Echinococcus granulosus | EgrG_000637300 | Microtubule associated protein RP:EB family |
Echinococcus multilocularis | EmuJ_000637300 | Microtubule associated protein RP:EB family |
Giardia lamblia | GL50803_14048 | EB1 |
Homo sapiens | ENSG00000101367 | microtubule-associated protein, RP/EB family, member 1 |
Homo sapiens | ENSG00000166974 | microtubule-associated protein, RP/EB family, member 2 |
Loa Loa (eye worm) | LOAG_03147 | EBF3-S |
Loa Loa (eye worm) | LOAG_13950 | microtubule binding protein |
Mus musculus | ENSMUSG00000027479 | microtubule-associated protein, RP/EB family, member 1 |
Mus musculus | ENSMUSG00000024277 | microtubule-associated protein, RP/EB family, member 2 |
Neospora caninum | NCLIV_045630 | APC binding protein EB1, related |
Oryza sativa | 4349023 | Os10g0498900 |
Oryza sativa | 4337174 | Os04g0642100 |
Onchocerca volvulus | OVOC12880 |
|
Plasmodium berghei | PBANKA_0405600 | microtubule-associated protein RP/EB family, putative |
Plasmodium falciparum | PF3D7_0307300 | microtubule-associated protein RP/EB family, putative |
Plasmodium knowlesi | PKNH_0835400 | microtubule-associated protein RP/EB family, putative |
Plasmodium vivax | PVX_119485 | microtubule associated protein EB1, putative |
Plasmodium yoelii | PY06631 | Putative homologue of Human EB1 protein-related |
Saccharomyces cerevisiae | YER016W | Bim1p |
Schistosoma japonicum | Sjp_0085580 | ko:K10436 microtubule-associated protein, RP/EB family, putative |
Schistosoma mansoni | Smp_054540 | microtubule-associated protein rp/eb family |
Schmidtea mediterranea | mk4.000575.05 | Putative microtubule-associated protein, rp/eb family |
Schmidtea mediterranea | mk4.000046.05 | Putative microtubule-associated protein, rp/eb family |
Schmidtea mediterranea | mk4.000729.04 | Putative microtubule-associated protein, rp/eb family |
Toxoplasma gondii | TGME49_227650 | microtubule-associated protein RP/EB family, putative |
Theileria parva | TP03_0743 | microtubule associated protein, putative |
Trichomonas vaginalis | TVAG_146390 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_228400 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_266680 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_381030 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
YER016W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0405600 | Plasmodium berghei | Dispensable | plasmo |
TGME49_227650 | Toxoplasma gondii | Essentiality uncertain | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.