Detailed view for TVAG_414030

Basic information

TDR Targets ID: 909336
Trichomonas vaginalis, oxidoreductases, putative
Source Database / ID: 

pI: 6.3802 | Length (AA): 322 | MW (Da): 35472 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01408   Oxidoreductase family, NAD-binding Rossmann fold

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128107)

Species Accession Gene Product
Arabidopsis thaliana AT1G34200   glyceraldehyde-3-phosphate dehydrogenase-like protein
Arabidopsis thaliana AT1G66130   NAD(P)-binding Rossmann-fold superfamily protein
Candida albicans CaO19.9584   possible dimeric dihydrodiol dehydrogenase
Candida albicans CaO19.2036   possible dimeric dihydrodiol dehydrogenase
Drosophila melanogaster Dmel_CG3609   CG3609 gene product from transcript CG3609-RA
Drosophila melanogaster Dmel_CG3597   CG3597 gene product from transcript CG3597-RA
Escherichia coli b3087   putative NAD(P)-dependent dehydrogenase
Homo sapiens ENSG00000104808   dihydrodiol dehydrogenase (dimeric)
Mus musculus ENSMUSG00000011382   dihydrodiol dehydrogenase (dimeric)
Mycobacterium tuberculosis Rv1752   Conserved hypothetical protein
Mycobacterium ulcerans MUL_3103   hypothetical protein
Schmidtea mediterranea mk4.000935.04  
Schmidtea mediterranea mk4.000533.00  
Schmidtea mediterranea mk4.000533.01  
Trichomonas vaginalis TVAG_414030   oxidoreductases, putative

Essentiality

TVAG_414030 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1782 Mycobacterium tuberculosis non-essential nmpdr
b3087 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_414030 (Trichomonas vaginalis), oxidoreductases, putative
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